BACKGROUND/AIMS: To analyze treatment and survival in a series of 39 patients with primary or recurrent retroperitoneal sarcoma treated and prospectively followed at a single institution. METHODOLOGY: Between July 1994 and January 2002, 39 patients (20M, 19F; mean age: 56 years, range: 25-77) were evaluated. RESULTS: Thirty-two out of 39 patients (82%) (18 were affected by primary retroperitoneal sarcoma, and 14 by recurrent retroperitoneal sarcoma), were submitted for resection. Twenty-four out of 32 patients (75%) underwent removal of contiguous intra-abdominal organs. Peroperative mortality was nil and significant peroperative complications occurred in 6 cases only (19%). High tumor grade results were a significant variable for a worse survival in all 32 patients (100% 5 years survival for low grade vs. 0% for high grade; P=0.0004). Among 27 radically resected patients, only histology gradeand peroperative blood transfusions affected survival (100% 5-year survival for low grade vs. 24% for high grade; P=0.003); (100% 5-year survival for nontransfused patients vs. 43% for transfused patients; P=0.03). Similar effects were noted for disease-free survival. CONCLUSIONS: Histology grade and peroperative blood transfusions were the only factors which affected overall and disease-free survival. An aggressive surgical approach in both primary and recurrent retroperitoneal sarcoma is associated with long-term survival.
BACKGROUND/AIMS: To analyze treatment and survival in a series of 39 patients with primary or recurrent retroperitoneal sarcoma treated and prospectively followed at a single institution. METHODOLOGY: Between July 1994 and January 2002, 39 patients (20M, 19F; mean age: 56 years, range: 25-77) were evaluated. RESULTS: Thirty-two out of 39 patients (82%) (18 were affected by primary retroperitoneal sarcoma, and 14 by recurrent retroperitoneal sarcoma), were submitted for resection. Twenty-four out of 32 patients (75%) underwent removal of contiguous intra-abdominal organs. Peroperative mortality was nil and significant peroperative complications occurred in 6 cases only (19%). High tumor grade results were a significant variable for a worse survival in all 32 patients (100% 5 years survival for low grade vs. 0% for high grade; P=0.0004). Among 27 radically resected patients, only histology gradeand peroperative blood transfusions affected survival (100% 5-year survival for low grade vs. 24% for high grade; P=0.003); (100% 5-year survival for nontransfused patients vs. 43% for transfused patients; P=0.03). Similar effects were noted for disease-free survival. CONCLUSIONS: Histology grade and peroperative blood transfusions were the only factors which affected overall and disease-free survival. An aggressive surgical approach in both primary and recurrent retroperitoneal sarcoma is associated with long-term survival.
Authors: Antonio Chiappa; Emilio Bertani; Gabriella Pravettoni; Andrew Paul Zbar; Diego Foschi; Giuseppe Spinoglio; Bernardo Bonanni; Gianluca Polvani; Federico Ambrogi; Maria Laura Cossu; Carlo Ferrari; Marco Venturino; Cristiano Crosta; Luca Bocciolone; Roberto Biffi Journal: Indian J Surg Date: 2018-01-31 Impact factor: 0.656
Authors: Wirginiusz Dziewirski; Piotr Rutkowski; Zbigniew I Nowecki; Tadeusz Morysinski; Maciej Sałamacha; Anna Kulik; Maria Kawczynska; Anetta Kasprowicz; Jarosław Łyczek; Włodzimierz Ruka Journal: J Contemp Brachytherapy Date: 2010-04-01