| Literature DB >> 15358082 |
I Pinilla1, R D Lund, Y Sauvé.
Abstract
Although the RCS rat is widely used as a model of progressive photoreceptor loss, it is unclear how the relative rod and cone functions change with age. Rod and cone b-waves were isolated using a double flash ERG paradigm. In contrast to cones, rods never reached normal functional maturity levels, and the ERG b-wave changed from being predominantly rod-driven to being purely cone-driven by age 74 days, at which point, b-waves were progressively replaced by negative STR-like (scotopic threshold response) waves that persisted up to age 180 days. A double flash commonly abolished this wave and unveiled a b-wave.Entities:
Mesh：
Year: 2004 PMID： 15358082 DOI： 10.1016/j.visres.2004.05.020
Source DB: PubMed Journal: Vision Res ISSN： 0042-6989 Impact factor: 1.886