Literature DB >> 15357989

Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia.

Jean Jacques Vanden Eynde1, Annie Mayence, Tien L Huang, Margaret S Collins, Sandra Rebholz, Peter D Walzer, Melanie T Cushion.   

Abstract

A series of pentamidine congeners has been synthesized and screened for their in vitro activity against Pneumocystis carinii. Among the tested compounds, bisbenzamidines linked by a flexible pentanediamide or hexanediamide chain (7 and 9) emerged as exceptionally potent agents that were more effective and less toxic than pentamidine in the assays described in this study.

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Year:  2004        PMID： 15357989     DOI： 10.1016/j.bmcl.2004.06.034

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  In vitro selection and in vivo efficacy of piperazine- and alkanediamide-linked bisbenzamidines against Pneumocystis pneumonia in mice.

Authors:  Melanie T Cushion; Peter D Walzer; Alan Ashbaugh; Sandra Rebholz; Ronald Brubaker; Jean Jacques Vanden Eynde; Annie Mayence; Tien L Huang
Journal:  Antimicrob Agents Chemother       Date:  2006-07       Impact factor: 5.191

2.  Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors.

Authors:  Michael L Berger; Dorota Maciejewska; Jean Jacques Vanden Eynde; Madhusoodanan Mottamal; Jerzy Żabiński; Paweł Kaźmierczak; Mateusz Rezler; Ivana Jarak; Ivo Piantanida; Grace Karminski-Zamola; Annie Mayence; Patrick Rebernik; Arvind Kumar; Mohamed A Ismail; David W Boykin; Tien L Huang
Journal:  Bioorg Med Chem       Date:  2015-06-14       Impact factor: 3.641

3.  Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity.

Authors:  Tien L Huang; Jean Jacques Vanden Eynde; Annie Mayence; Margaret S Collins; Melanie T Cushion; Donna Rattendi; Indira Londono; Lakshman Mazumder; Cyrus J Bacchi; Nigel Yarlett
Journal:  Bioorg Med Chem Lett       Date:  2009-08-23       Impact factor: 2.823

4.  Imidazoquines as antimalarial and antipneumocystis agents.

Authors:  Nuno Vale; Miguel Prudêncio; Catarina A Marques; Margaret S Collins; Jiri Gut; Fátima Nogueira; Joana Matos; Philip J Rosenthal; Melanie T Cushion; Virgílio E do Rosário; Maria M Mota; Rui Moreira; Paula Gomes
Journal:  J Med Chem       Date:  2009-12-10       Impact factor: 7.446

5.  Structural aspects of intermolecular interactions in the solid state of 1,4-dibenzylpiperazines bearing nitrile or amidine groups.

Authors:  Mateusz Rezler; Teresa Żołek; Irena Wolska; Dorota Maciejewska
Journal:  Acta Crystallogr B Struct Sci Cryst Eng Mater       Date:  2014-09-18

6.  Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents.

Authors:  Jean J Vanden Eynde; Annie Mayence; Madhusoodanan Mottamal; Cyrus J Bacchi; Nigel Yarlett; Marcel Kaiser; Reto Brun; Tien L Huang
Journal:  Pharmaceuticals (Basel)       Date:  2016-04-19

7.  Bisbenzamidines as antifungal agents. are both amidine functions required to observe an anti-Pneumocystis carinii activity?

Authors:  Julien Laurent; Dimitri Stanicki; Tien L Huang; Eduardo Dei-Cas; Muriel Pottier; El Mouktar Aliouat; Jean Jacques Vanden Eynde
Journal:  Molecules       Date:  2010-06-11       Impact factor: 4.411

8.  Development of highly active anti-Pneumocystis bisbenzamidines: insight into the influence of selected substituents on the in vitro activity.

Authors:  D Maciejewska; J Żabiński; M Rezler; P Kaźmierczak; M S Collins; L Ficker; M T Cushion
Journal:  Medchemcomm       Date:  2017-10-05       Impact factor: 3.597

9.  Design and synthesis of N¹,N⁵-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as potential antifungal prodrugs.

Authors:  Nageswara Rao Kode; Jean J Vanden Eynde; Annie Mayence; Guangdi Wang; Tien L Huang
Journal:  Molecules       Date:  2013-09-12       Impact factor: 4.411

10.  HIV chromatin is a preferred target for drugs that bind in the DNA minor groove.

Authors:  Clayton K Collings; Donald W Little; Samuel J Schafer; John N Anderson
Journal:  PLoS One       Date:  2019-12-30       Impact factor: 3.240
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