Literature DB >> 15357977

Cytotoxic effects and reversal of multidrug resistance by ibogan and related indole alkaloids.

Toh-Seok Kam1, Kooi-Mow Sim, Huey-Shen Pang, Takashi Koyano, Masahiko Hayashi, Kanki Komiyama.   

Abstract

A series of indole alkaloids of the ibogan-type was assessed for their cytotoxic effects as well as their potential in reversing MDR in vincristine-resistant KB cells. Of a total of 25 compounds tested, 3(S)-cyanocoronaridine, 3(S)-cyanoisovoacangine, 3(S)-cyanovoacangine, and 10,11-demethoxychippiine were found to show appreciable cytotoxicity toward KB cells, while coronaridine, heyneanine, 19-epi-heyneanine, dippinine B, and dippinine C, were found to reverse MDR in vincristine-resistant KB cells.

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Year:  2004        PMID： 15357977     DOI： 10.1016/j.bmcl.2004.06.074

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

Review 1.  Synthesis of indole derivatives as prevalent moieties present in selected alkaloids.

Authors:  Majid M Heravi; Zahra Amiri; Kosar Kafshdarzadeh; Vahideh Zadsirjan
Journal:  RSC Adv       Date:  2021-10-15       Impact factor: 4.036

2.  Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents.

Authors:  Michael Wink; Mohamed L Ashour; Mahmoud Zaki El-Readi
Journal:  Front Microbiol       Date:  2012-04-23       Impact factor: 5.640

Review 3.  Natural Products as Alternative Choices for P-Glycoprotein (P-gp) Inhibition.

Authors:  Saikat Dewanjee; Tarun K Dua; Niloy Bhattacharjee; Anup Das; Moumita Gangopadhyay; Ritu Khanra; Swarnalata Joardar; Muhammad Riaz; Vincenzo De Feo; Muhammad Zia-Ul-Haq
Journal:  Molecules       Date:  2017-05-25       Impact factor: 4.411

4.  Acaricidal activity of the aqueous and hydroethanolic extracts of 15 South African plants against Rhipicephalus turanicus and their toxicity on human liver and kidney cells.

Authors:  Gerda Fouche; Olubukola T Adenubi; Tlabo Leboho; Lyndy J McGaw; Vinny Naidoo; Kevin W Wellington; Jacobus N Eloff
Journal:  Onderstepoort J Vet Res       Date:  2019-07-22       Impact factor: 1.792

5.  Cytotoxicity and genotoxicity of coronaridine from Tabernaemontana catharinensis A.DC in a human laryngeal epithelial carcinoma cell line (Hep-2).

Authors:  Walace Fraga Rizo; Luis Eduardo Ferreira; Vanessa Colnaghi; Juliana Simões Martins; Leonardo Pereira Franchi; Catarina Satie Takahashi; Rene Oliveira Beleboni; Mozart Marins; Paulo Sérgio Pereira; Ana Lúcia Fachin
Journal:  Genet Mol Biol       Date:  2013-03-04       Impact factor: 1.771
  5 in total

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