| Literature DB >> 15357584 |
Matthew M Bio1, Feng Xu, Marjorie Waters, J Michael Williams, Kimberly A Savary, Cameron J Cowden, Chunhua Yang, Elizabeth Buck, Zhiguo J Song, David M Tschaen, R P Volante, Robert A Reamer, Edward J J Grabowski.
Abstract
A practical, efficient synthesis of 1, a hepatitis C virus RNA replication inhibitor, is described. Starting with the inexpensive diacetone glucose, the 12-step synthesis features a novel stereoselective rearrangement to prepare the key crystalline furanose diol intermediate. This is followed by a highly selective glycosidation to couple the C-2 branched furanose epoxide with deazapurine.Entities:
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Year: 2004 PMID： 15357584 DOI： 10.1021/jo0491096
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354