Literature DB >> 15356996

Synthesis and antitubercular activity of 6-chloro (unsubstituted)- 2-methoxy-9-substituted acridine derivatives.

Enayat I Aly1, Ashraf H Abadi.   

Abstract

Several analogues of the general formulae 2-methoxy-9-substituted acridine and 6-chloro-2-methoxy-9-substituted acridine were synthesized and evaluated in vitro at 6.25 microg/mL against M. tuberculosis H37Rv. Compounds 15 and 17 showed potential antitubercular activity with 100% inhibition to the virulent mycobacterium.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15356996     DOI： 10.1007/bf02980137

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  2 in total

1.  Crystal structure, Hirshfeld surface and frontier mol-ecular orbital analysis of 10-benzyl-9-(4-hydroxy-3-meth-oxy-phen-yl)-3,3,6,6-tetra-methyl-3,4,6,7,9,10-hexa-hydro-acridine-1,8(2H,5H)-dione.

Authors:  V Sughanya; B Loganathan; D Praveenkumar; J Ayyappan; M L Sundararajan; A Prabhakaran; A Dhandapani; N Suresh Babu
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2022-07-14

2.  The structure of 9-(3-bromo-6-chloro-2-hy-droxy-phen-yl)-10-(2-hy-droxy-ethyl)-3,6-diphenyl-3,4,5,6,7,9-hexa-hydro-2H-acridine-1,8-dione.

Authors:  Antar A Abdelhamid; Farouq E Hawaiz; Alaa F Mohamed; Shaaban K Mohamed; Jim Simpson
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2018-08-14
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.