Literature DB >> 15356349

TOR pathway: linking nutrient sensing to life span.

Pankaj Kapahi1, Brian Zid.   

Abstract

Recent studies point to an emerging role for the TOR (target of rapamycin) pathway in the regulation of life span. In this Perspective, we discuss the possibility that this pathway is an important modulator of nutrient-dependent changes in life span. Additionally, we discuss the interactions between the TOR and insulin-like signaling pathways as well as the key downstream processes that TOR regulates.

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Year:  2004        PMID： 15356349      PMCID： PMC2754831          DOI： 10.1126/sageke.2004.36.pe34

Source DB:  PubMed          Journal:  Sci Aging Knowledge Environ        ISSN： 1539-6150


  30 in total

1.  Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway.

Authors:  Tor Erik Rusten; Karine Lindmo; Gábor Juhász; Miklós Sass; Per O Seglen; Andreas Brech; Harald Stenmark
Journal:  Dev Cell       Date:  2004-08       Impact factor: 12.270

2.  Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway.

Authors:  D Zaragoza; A Ghavidel; J Heitman; M C Schultz
Journal:  Mol Cell Biol       Date:  1998-08       Impact factor: 4.272

3.  Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap.

Authors:  A Lazaris-Karatzas; K S Montine; N Sonenberg
Journal:  Nature       Date:  1990-06-07       Impact factor: 49.962

4.  Food, reproduction and longevity: is the extended lifespan of calorie-restricted animals an evolutionary adaptation?

Authors:  R Holliday
Journal:  Bioessays       Date:  1989-04       Impact factor: 4.345

5.  Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.

Authors:  J Heitman; N R Movva; M N Hall
Journal:  Science       Date:  1991-08-23       Impact factor: 47.728

6.  The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span.

Authors:  Kailiang Jia; Di Chen; Donald L Riddle
Journal:  Development       Date:  2004-07-14       Impact factor: 6.868

7.  The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease.

Authors:  A Schmidt; T Beck; A Koller; J Kunz; M N Hall
Journal:  EMBO J       Date:  1998-12-01       Impact factor: 11.598

Review 8.  Effect of caloric restriction on age-associated cancers.

Authors:  R Weindruch
Journal:  Exp Gerontol       Date:  1992 Sep-Dec       Impact factor: 4.032

9.  Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans.

Authors:  Barbara Meissner; Michael Boll; Hannelore Daniel; Ralf Baumeister
Journal:  J Biol Chem       Date:  2004-05-19       Impact factor: 5.157

10.  Target of rapamycin-mediated amino acid signaling in mosquito anautogeny.

Authors:  Immo A Hansen; Geoffrey M Attardo; Jong-Hwa Park; Quan Peng; Alexander S Raikhel
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-30       Impact factor: 12.779
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  36 in total

Review 1.  Calorie restriction: what recent results suggest for the future of ageing research.

Authors:  Daniel L Smith; Tim R Nagy; David B Allison
Journal:  Eur J Clin Invest       Date:  2010-05       Impact factor: 4.686

2.  Molecular basis of ageing.

Authors:  Matt Kaeberlein
Journal:  EMBO Rep       Date:  2007-09-07       Impact factor: 8.807

Review 3.  Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones.

Authors:  Nir Barzilai; Andrzej Bartke
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2009-02-19       Impact factor: 6.053

4.  Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistance.

Authors:  Francine H Einstein; Sigal Fishman; Jeffery Bauman; Reid F Thompson; Derek M Huffman; Gil Atzmon; Nir Barzilai; Radhika H Muzumdar
Journal:  FASEB J       Date:  2008-06-19       Impact factor: 5.191

Review 5.  Aging as an event of proteostasis collapse.

Authors:  Rebecca C Taylor; Andrew Dillin
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-05-01       Impact factor: 10.005

Review 6.  Rapamycin and ageing: when, for how long, and how much?

Authors:  Matt Kaeberlein
Journal:  J Genet Genomics       Date:  2014-08-07       Impact factor: 4.275

7.  Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1.

Authors:  Matthew A Schreiber; Jonathan T Pierce-Shimomura; Stefan Chan; Dianne Parry; Steven L McIntire
Journal:  PLoS Genet       Date:  2010-05-27       Impact factor: 5.917

8.  The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1.

Authors:  Gino Heeren; Mark Rinnerthaler; Peter Laun; Phyllis von Seyerl; Sonja Kössler; Harald Klinger; Matthias Hager; Edith Bogengruber; Stefanie Jarolim; Birgit Simon-Nobbe; Christoph Schüller; Didac Carmona-Gutierrez; Lore Breitenbach-Koller; Christoph Mück; Pidder Jansen-Dürr; Alfredo Criollo; Guido Kroemer; Frank Madeo; Michael Breitenbach
Journal:  Aging (Albany NY)       Date:  2009-07-13       Impact factor: 5.682

Review 9.  Sestrins at the crossroad between stress and aging.

Authors:  Jun Hee Lee; Rolf Bodmer; Ethan Bier; Michael Karin
Journal:  Aging (Albany NY)       Date:  2010-06       Impact factor: 5.682

10.  Macronutrient balance and lifespan.

Authors:  Stephen J Simpson; David Raubenheimer
Journal:  Aging (Albany NY)       Date:  2009-10-22       Impact factor: 5.682
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