BACKGROUND: A negative association of oro-faecally spread infection with serological markers of sensitization and allergic disease has been reported. METHOD: Previous infection with hepatitis A and Helicobacter pylori was assessed in a community-based sample of young British adults and associations with serum-specific IgE to environmental allergens, asthma-like symptoms and hay fever were examined. RESULTS: There was no association of previous infection with hepatitis A or H. pylori with wheeze or hay fever. There was no evidence of an association of infection with either agent and sensitization except for the isolated finding of a lower prevalence of sensitization to grass in those with IgG antibodies to H. pylori (OR 0.65, 95% CI 0.43-0.99). This association did not explain the negative association of family size with sensitization to grass. CONCLUSION: In this population, there was no evidence that infection with hepatitis A or H. pylori was associated with lower levels of IgE sensitization, asthma or hay fever except for an isolated finding of a negative association of H. pylori infection with sensitization to grass.
BACKGROUND: A negative association of oro-faecally spread infection with serological markers of sensitization and allergic disease has been reported. METHOD: Previous infection with hepatitis A and Helicobacter pylori was assessed in a community-based sample of young British adults and associations with serum-specific IgE to environmental allergens, asthma-like symptoms and hay fever were examined. RESULTS: There was no association of previous infection with hepatitis A or H. pylori with wheeze or hay fever. There was no evidence of an association of infection with either agent and sensitization except for the isolated finding of a lower prevalence of sensitization to grass in those with IgG antibodies to H. pylori (OR 0.65, 95% CI 0.43-0.99). This association did not explain the negative association of family size with sensitization to grass. CONCLUSION: In this population, there was no evidence that infection with hepatitis A or H. pylori was associated with lower levels of IgE sensitization, asthma or hay fever except for an isolated finding of a negative association of H. pyloriinfection with sensitization to grass.
Authors: Umur Akiner; H Murat Yener; E Deniz Gozen; S Burcu Kuzu; Salih Canakcioglu Journal: Eur Arch Otorhinolaryngol Date: 2019-09-25 Impact factor: 2.503
Authors: I Lisanne Holster; Anne Marie J Vila; Daan Caudri; Caroline M den Hoed; Guillermo I Perez-Perez; Martin J Blaser; Johan C de Jongste; Ernst J Kuipers Journal: Helicobacter Date: 2012-03-20 Impact factor: 5.753
Authors: Lucia Pacifico; John F Osborn; Valeria Tromba; Sara Romaggioli; Stefano Bascetta; Claudio Chiesa Journal: World J Gastroenterol Date: 2014-02-14 Impact factor: 5.742