Literature DB >> 15342603

Bacterial thymidylate synthase with intein, group II Intron, and distinctive ThyX motifs.

Xiang-Qin Liu1, Jing Yang.   

Abstract

The ThyX class of thymidylate synthases was previously characterized by a common ThyX motif, RHRX7S. We report bacterial ThyX sequences having distinctive ThyX motifs, suggesting a more general ThyX motif, R/THRX7-8S. One ThyX sequence has an intein in its ThyX motif that was shown to do protein splicing and a group II intron in its gene, suggesting a hot spot for these self-splicing mobile elements.

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Year:  2004        PMID： 15342603      PMCID： PMC515151          DOI： 10.1128/JB.186.18.6316-6319.2004

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  22 in total

1.  Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers.

Authors:  Damien Leduc; Sébastien Graziani; Gerard Lipowski; Christophe Marchand; Pierre Le Maréchal; Ursula Liebl; Hannu Myllykallio
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-27       Impact factor: 11.205

2.  Four inteins and three group II introns encoded in a bacterial ribonucleotide reductase gene.

Authors:  Xiang-Qin Liu; Jing Yang; Qing Meng
Journal:  J Biol Chem       Date:  2003-09-15       Impact factor: 5.157

3.  Protein trans-splicing and functional mini-inteins of a cyanobacterial dnaB intein.

Authors:  H Wu; M Q Xu; X Q Liu
Journal:  Biochim Biophys Acta       Date:  1998-09-08

4.  Introns and intein coding sequence in the ribonucleotide reductase genes of Bacillus subtilis temperate bacteriophage SPbeta.

Authors:  V Lazarevic; B Soldo; A Düsterhöft; H Hilbert; C Mauël; D Karamata
Journal:  Proc Natl Acad Sci U S A       Date:  1998-02-17       Impact factor: 11.205

Review 5.  Homing endonucleases: keeping the house in order.

Authors:  M Belfort; R J Roberts
Journal:  Nucleic Acids Res       Date:  1997-09-01       Impact factor: 16.971

Review 6.  Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

Authors:  S F Altschul; T L Madden; A A Schäffer; J Zhang; Z Zhang; W Miller; D J Lipman
Journal:  Nucleic Acids Res       Date:  1997-09-01       Impact factor: 16.971

Review 7.  Protein splicing: self-splicing of genetically mobile elements at the protein level.

Authors:  A A Cooper; T H Stevens
Journal:  Trends Biochem Sci       Date:  1995-09       Impact factor: 13.807

8.  Protein splicing elements: inteins and exteins--a definition of terms and recommended nomenclature.

Authors:  F B Perler; E O Davis; G E Dean; F S Gimble; W E Jack; N Neff; C J Noren; J Thorner; M Belfort
Journal:  Nucleic Acids Res       Date:  1994-04-11       Impact factor: 16.971

Review 9.  Mechanisms of intron mobility.

Authors:  M Belfort; P S Perlman
Journal:  J Biol Chem       Date:  1995-12-22       Impact factor: 5.157

10.  An 8 kb nucleotide sequence at the 3' flanking region of the sspC gene (184 degrees) on the Bacillus subtilis 168 chromosome containing an intein and an intron.

Authors:  S Y Ghim; S K Choi; B S Shin; S H Park
Journal:  DNA Res       Date:  1998-04-30       Impact factor: 4.458
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  6 in total

1.  Unusual group II introns in bacteria of the Bacillus cereus group.

Authors:  Nicolas J Tourasse; Fredrik B Stabell; Lillian Reiter; Anne-Brit Kolstø
Journal:  J Bacteriol       Date:  2005-08       Impact factor: 3.490

2.  Detection of a group II intron without an open reading frame in the alpha-toxin gene of Clostridium perfringens isolated from a broiler chicken.

Authors:  Menglin Ma; Kaori Ohtani; Tohru Shimizu; Naoaki Misawa
Journal:  J Bacteriol       Date:  2006-12-08       Impact factor: 3.490

3.  Functional analysis of the Mycobacterium tuberculosis FAD-dependent thymidylate synthase, ThyX, reveals new amino acid residues contributing to an extended ThyX motif.

Authors:  Jonathan E Ulmer; Yap Boum; Christopher D Thouvenel; Hannu Myllykallio; Carol Hopkins Sibley
Journal:  J Bacteriol       Date:  2008-01-11       Impact factor: 3.490

4.  The primary transcriptome of the marine diazotroph Trichodesmium erythraeum IMS101.

Authors:  Ulrike Pfreundt; Matthias Kopf; Natalia Belkin; Ilana Berman-Frank; Wolfgang R Hess
Journal:  Sci Rep       Date:  2014-08-26       Impact factor: 4.379

Review 5.  Flavin-Dependent Thymidylate Synthase as a New Antibiotic Target.

Authors:  Michael Choi; Kalani Karunaratne; Amnon Kohen
Journal:  Molecules       Date:  2016-05-20       Impact factor: 4.411

6.  Sequential splicing of a group II twintron in the marine cyanobacterium Trichodesmium.

Authors:  Ulrike Pfreundt; Wolfgang R Hess
Journal:  Sci Rep       Date:  2015-11-18       Impact factor: 4.379
  6 in total

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