| Literature DB >> 15340428 |
Abstract
Mice deficient in the metalloprotease inhibitor TIMP3, which inhibits the tumor-necrosis factor alpha (TNF-alpha)-converting enzyme (TACE, also called ADAM17), have elevated levels of TNF and severe inflammation in the liver. This result confirms the physiological importance of the soluble form of TNF and identifies TIMP3 as a crucial regulator of this inflammatory cytokine.Entities:
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Year: 2004 PMID： 15340428 DOI： 10.1038/ng0904-934
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330