Literature DB >> 21603393

Improving Donor Livers by Inhibiting TNF-α Production.

Christopher P Zetzmann1, O Rama Swamy, George E Loss, Humberto Bohorquez, Ari J Cohen.   

Abstract

Hepatic ischemia/reperfusion (I/R) injury has a significant influence on the outcome of liver transplants. Inhibiting certain enzymatic reactions that occur during I/R injury may have a protective effect on the liver during transplantation. After reviewing the biochemical pathways involved in hepatic I/R injury, we describe a pharmacologic line of defense against this injury by means of the enzyme tissue inhibitor of metalloproteinase 3 (TIMP-3). Current results suggest that TIMP-3 will play a clinically relevant role in improving outcomes of liver transplants by reducing I/R injury to the donor liver.

Entities:  

Keywords:  Hepatic ischemia/reperfusion; TIMP-3; liver

Year:  2010        PMID： 21603393      PMCID： PMC3096233     

Source DB:  PubMed          Journal:  Ochsner J        ISSN： 1524-5012


  34 in total

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Journal:  Annu Rev Immunol       Date:  1992       Impact factor: 28.527

2.  Evaluation of microperfusion disturbances in the transplanted liver after Kupffer cell destruction using GdCl3: an experimental porcine study.

Authors:  C Jahnke; A Mehrabi; M Golling; M V Frankenberg; A Kashfi; H Nentwich; H Fonouni; A Nickkholgh; P Schemmer; C N Gutt; J Weitz; J Schmidt; M M Gebhard; M W Büchler; Th Kraus
Journal:  Transplant Proc       Date:  2006-06       Impact factor: 1.066

3.  Up-regulation of TNF-alpha convertase (TACE/ADAM17) after oxygen-glucose deprivation in rat forebrain slices.

Authors:  O Hurtado; A Cárdenas; I Lizasoain; L Boscá; J C Leza; P Lorenzo; M A Moro
Journal:  Neuropharmacology       Date:  2001-06       Impact factor: 5.250

4.  Importance of tumor necrosis factor-alpha cleavage process in post-transplantation lung injury in rats.

Authors:  Taichiro Goto; Akitoshi Ishizaka; Fujio Kobayashi; Mitsutomo Kohno; Makoto Sawafuji; Sadatomo Tasaka; Eiji Ikeda; Yasunori Okada; Ikuro Maruyama; Koichi Kobayashi
Journal:  Am J Respir Crit Care Med       Date:  2004-08-27       Impact factor: 21.405

5.  Interleukin 13 gene transfer in liver ischemia and reperfusion injury: role of Stat6 and TLR4 pathways in cytoprotection.

Authors:  Bibo Ke; Xiu-Da Shen; Feng Gao; Ronald W Busuttil; Jerzy W Kupiec-Weglinski
Journal:  Hum Gene Ther       Date:  2004-07       Impact factor: 5.695

6.  Hypertonic preconditioning prevents hepatocellular injury following ischemia/reperfusion in mice: a role for interleukin 10.

Authors:  George D Oreopoulos; Heshui Wu; Kati Szaszi; Jie Fan; John C Marshall; Rachel G Khadaroo; Ruijan He; Andras Kapus; Ori D Rotstein
Journal:  Hepatology       Date:  2004-07       Impact factor: 17.425

7.  Adenine nucleotide tissue concentrations and liver allograft viability after cold preservation and warm ischemia.

Authors:  P R Harvey; S Iu; C M McKeown; C N Petrunka; R G Ilson; S M Strasberg
Journal:  Transplantation       Date:  1988-06       Impact factor: 4.939

8.  In vitro ischemic tolerance involves upregulation of glutamate transport partly mediated by the TACE/ADAM17-tumor necrosis factor-alpha pathway.

Authors:  Cristina Romera; Olivia Hurtado; Sofia H Botella; Ignacio Lizasoain; Antonio Cárdenas; Paz Fernández-Tomé; Juan C Leza; Pedro Lorenzo; Maria A Moro
Journal:  J Neurosci       Date:  2004-02-11       Impact factor: 6.167

9.  Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats.

Authors:  Xinkang Wang; Giora Z Feuerstein; Lin Xu; Hugh Wang; William A Schumacher; Martin L Ogletree; Rebecca Taub; James J-W Duan; Carl P Decicco; Rui-Qin Liu
Journal:  Mol Pharmacol       Date:  2004-04       Impact factor: 4.436

10.  Low-dose TNF-alpha protects against hepatic ischemia-reperfusion injury in mice: implications for preconditioning.

Authors:  Narci Teoh; Isabelle Leclercq; Aileen Dela Pena; Geoffrey Farrell
Journal:  Hepatology       Date:  2003-01       Impact factor: 17.425
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  4 in total

1.  The protective role of CD59 and pathogenic role of complement in hepatic ischemia and reperfusion injury.

Authors:  Jinyan Zhang; Weiguo Hu; Wei Xing; Tao You; Junming Xu; Xuebin Qin; Zhihai Peng
Journal:  Am J Pathol       Date:  2011-10-19       Impact factor: 4.307

2.  Tumor Necrosis Factor-α: Life and Death of Hepatocytes During Liver Ischemia/Reperfusion Injury.

Authors:  Maureen Shuh; Humberto Bohorquez; George E Loss; Ari J Cohen
Journal:  Ochsner J       Date:  2013

3.  Paeoniflorin attenuates hepatic ischemia/reperfusion injury via anti-oxidative, anti-inflammatory and anti-apoptotic pathways.

Authors:  Y E Tao; Zhihong Wen; Yingqian Song; Hui Wang
Journal:  Exp Ther Med       Date:  2015-11-27       Impact factor: 2.447

4.  Astaxanthin prevents ischemia-reperfusion injury of the steatotic liver in mice.

Authors:  Shaowei Li; Terumi Takahara; Masayuki Fujino; Yasuyuki Fukuhara; Toshiro Sugiyama; Xiao-Kang Li; Shiro Takahara
Journal:  PLoS One       Date:  2017-11-09       Impact factor: 3.240
  4 in total

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