BACKGROUND: Data on determinants of persistence of major depressive episodes (MDE) are inconsistent due to methodological shortcomings of the studies involved. AIMS: To examine determinants of persistence of MDE in subjects from the general population (N=250) with new episodes of DSM-III-R major depression. METHOD: The Netherlands Mental Health Survey and Incidence Study is a prospective epidemiologic survey in the adult population (N=7076), using the Composite International Diagnostic Interview (CIDI). A broad range of potential determinants was assessed. RESULTS: Determinants of persistence were severity of the index episode, longer duration of previous episodes, (chronic) physical illness and lack of social support. A recurrent episode predicted shorter duration. LIMITATIONS: Follow-up was only 2 years and duration of episode was retrospectively assessed. CONCLUSIONS: Just as in clinical populations, illness-related factors seem to be the strongest predictors of persistence of MDE. A thorough assessment of each depressed patient on the predictors of persistence is advisable.
BACKGROUND: Data on determinants of persistence of major depressive episodes (MDE) are inconsistent due to methodological shortcomings of the studies involved. AIMS: To examine determinants of persistence of MDE in subjects from the general population (N=250) with new episodes of DSM-III-R major depression. METHOD: The Netherlands Mental Health Survey and Incidence Study is a prospective epidemiologic survey in the adult population (N=7076), using the Composite International Diagnostic Interview (CIDI). A broad range of potential determinants was assessed. RESULTS: Determinants of persistence were severity of the index episode, longer duration of previous episodes, (chronic) physical illness and lack of social support. A recurrent episode predicted shorter duration. LIMITATIONS: Follow-up was only 2 years and duration of episode was retrospectively assessed. CONCLUSIONS: Just as in clinical populations, illness-related factors seem to be the strongest predictors of persistence of MDE. A thorough assessment of each depressedpatient on the predictors of persistence is advisable.
Authors: J Angst; K R Merikangas; L Cui; A Van Meter; V Ajdacic-Gross; W Rössler Journal: Eur Arch Psychiatry Clin Neurosci Date: 2018-07-21 Impact factor: 5.270
Authors: William W Eaton; Huibo Shao; Gerald Nestadt; Hochang Benjamin Lee; Ben Hochang Lee; O Joseph Bienvenu; Peter Zandi Journal: Arch Gen Psychiatry Date: 2008-05
Authors: Katherine M Putnam; Diego A Pizzagalli; Diane C Gooding; Ned H Kalin; Richard J Davidson Journal: Psychophysiology Date: 2008-09-24 Impact factor: 4.016