| Literature DB >> 15332851 |
Yoichi Nakao1, Wesley Y Yoshida, Yuuki Takada, Junji Kimura, Liu Yang, Susan L Mooberry, Paul J Scheuer.
Abstract
A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation. Kulokekahilide-2 showed potent cytotoxicity against several cell lines (P388, SK-OV-3, MDA-MB-435, and A-10 with IC50 values ranging from 4.2 to 59.1 nM) indicating cancer cell selectivity.Entities:
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Year: 2004 PMID： 15332851 DOI： 10.1021/np049949f
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050