Literature DB >> 15332842

Palmitoylputrescine, an antibiotic isolated from the heterologous expression of DNA extracted from bromeliad tank water.

Sean F Brady1, Jon Clardy.   

Abstract

Heterologous expression of large fragments of microbial DNA extracted directly from environmental samples (environmental DNA, or eDNA) in easily cultured hosts should provide access to some of the natural products produced by previously uncultured bacteria. The natural product antibiotic palmitoylputrescine (1) was isolated from Escherichia coli transformed with a cosmid (pCSLF16) containing DNA extracted directly from Costa Rican bromeliad tank water. In this report we describe the characterization of this antibiotic and its biosynthetic gene.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15332842     DOI： 10.1021/np0499766

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  21 in total

1.  Novel antibacterial proteins from the microbial communities associated with the sponge Cymbastela concentrica and the green alga Ulva australis.

Authors:  Pui Yi Yung; Catherine Burke; Matt Lewis; Staffan Kjelleberg; Torsten Thomas
Journal:  Appl Environ Microbiol       Date:  2010-12-23       Impact factor: 4.792

Review 2.  Metagenomic approaches to natural products from free-living and symbiotic organisms.

Authors:  Sean F Brady; Luke Simmons; Jeffrey H Kim; Eric W Schmidt
Journal:  Nat Prod Rep       Date:  2009-09-16       Impact factor: 13.423

3.  Synthetic libraries of tyrosine-derived bacterial metabolites.

Authors:  Savvas N Georgiades; Jon Clardy
Journal:  Bioorg Med Chem Lett       Date:  2007-10-22       Impact factor: 2.823

4.  Expanding small-molecule functional metagenomics through parallel screening of broad-host-range cosmid environmental DNA libraries in diverse proteobacteria.

Authors:  Jeffrey W Craig; Fang-Yuan Chang; Jeffrey H Kim; Steven C Obiajulu; Sean F Brady
Journal:  Appl Environ Microbiol       Date:  2010-01-15       Impact factor: 4.792

5.  Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR.

Authors:  Jeffrey H Kim; Zhiyang Feng; John D Bauer; Dimitris Kallifidas; Paula Y Calle; Sean F Brady
Journal:  Biopolymers       Date:  2010-09       Impact factor: 2.505

6.  Gut-inhabiting Clostridia build human GPCR ligands by conjugating neurotransmitters with diet- and human-derived fatty acids.

Authors:  Fang-Yuan Chang; Piro Siuti; Stephane Laurent; Thomas Williams; Emerson Glassey; Andreas W Sailer; David Benjamin Gordon; Horst Hemmerle; Christopher A Voigt
Journal:  Nat Microbiol       Date:  2021-04-12       Impact factor: 17.745

Review 7.  Mining the metabiome: identifying novel natural products from microbial communities.

Authors:  Aleksandr Milshteyn; Jessica S Schneider; Sean F Brady
Journal:  Chem Biol       Date:  2014-09-18

Review 8.  Strategies for Natural Products Discovery from Uncultured Microorganisms.

Authors:  Khorshed Alam; Muhammad Nazeer Abbasi; Jinfang Hao; Youming Zhang; Aiying Li
Journal:  Molecules       Date:  2021-05-17       Impact factor: 4.411

9.  Assessing the effectiveness of functional genetic screens for the identification of bioactive metabolites.

Authors:  Anahit Penesyan; Francesco Ballestriero; Malak Daim; Staffan Kjelleberg; Torsten Thomas; Suhelen Egan
Journal:  Mar Drugs       Date:  2012-12-27       Impact factor: 5.118

Review 10.  Achievements and new knowledge unraveled by metagenomic approaches.

Authors:  Carola Simon; Rolf Daniel
Journal:  Appl Microbiol Biotechnol       Date:  2009-09-16       Impact factor: 4.813
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.