Literature DB >> 15332839

Nagelamides A-H, new dimeric bromopyrrole alkaloids from marine sponge Agelas species.

Tadashi Endo1, Masashi Tsuda, Tadashi Okada, Shinya Mitsuhashi, Hiroshi Shima, Kunimi Kikuchi, Yuzuru Mikami, Jane Fromont, Jun'ichi Kobayashi.   

Abstract

Eight new dimeric bromopyrrole alkaloids, nagelamides A-H (1-8) and a monomeric one, 9,10-dihydrokeramadine (9), have been isolated from the Okinawan marine sponge Agelas sp., and the structures were elucidated from spectroscopic data. Nagelamides A-H (1-8) exhibited antibacterial activity against Gram-positive bacteria. Nagelamide G (7) inhibited protein phosphatase 2A activity.

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Year:  2004        PMID： 15332839     DOI： 10.1021/np034077n

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  22 in total

Review 1.  Marine pharmacology in 2003-4: marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Mark T Hamann
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2007-02-09       Impact factor: 3.228

Review 2.  Bioactive cyclobutane-containing alkaloids.

Authors:  Valery M Dembitsky
Journal:  J Nat Med       Date:  2007-09-05       Impact factor: 2.343

3.  Antimicrobial metabolites from the Paracel Islands sponge Agelas mauritiana.

Authors:  Fan Yang; Mark T Hamann; Yike Zou; Ming-Yu Zhang; Xiao-Bin Gong; Jian-Ru Xiao; Wan-Sheng Chen; Hou-Wen Lin
Journal:  J Nat Prod       Date:  2012-02-23       Impact factor: 4.050

4.  Pyrrole aminoimidazole alkaloid metabiosynthesis with marine sponges Agelas conifera and Stylissa caribica.

Authors:  E Paige Stout; Yong-Gang Wang; Daniel Romo; Tadeusz F Molinski
Journal:  Angew Chem Int Ed Engl       Date:  2012-04-04       Impact factor: 15.336

5.  Syntheses of Cyclic Guanidine-Containing Natural Products.

Authors:  Yuyong Ma; Saptarshi De; Chuo Chen
Journal:  Tetrahedron       Date:  2015-02-25       Impact factor: 2.457

6.  Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel .

Authors:  George R Pettit; Yuping Tang; Qingwen Zhang; Gregory T Bourne; Christoph A Arm; John E Leet; John C Knight; Robin K Pettit; Jean-Charles Chapuis; Dennis L Doubek; Franklin J Ward; Christine Weber; John N A Hooper
Journal:  J Nat Prod       Date:  2013-02-14       Impact factor: 4.050

7.  A biomimetic route for construction of the [4+2] and [3+2] core skeletons of dimeric pyrrole-imidazole alkaloids and asymmetric synthesis of ageliferins.

Authors:  Xiao Wang; Xiaolei Wang; Xianghui Tan; Jianming Lu; Kevin W Cormier; Zhiqiang Ma; Chuo Chen
Journal:  J Am Chem Soc       Date:  2012-11-02       Impact factor: 15.419

8.  Total synthesis of the putative structure of nagelamide D.

Authors:  Manojkumar R Bhandari; Rasapalli Sivappa; Carl J Lovely
Journal:  Org Lett       Date:  2009-04-02       Impact factor: 6.005

9.  Cyclobutane-containing alkaloids: origin, synthesis, and biological activities.

Authors:  Anastasia Sergeiko; Vladimir V Poroikov; Lumir O Hanus; Valery M Dembitsky
Journal:  Open Med Chem J       Date:  2008-04-15

Review 10.  A submarine journey: the pyrrole-imidazole alkaloids.

Authors:  Barbara Forte; Beatrice Malgesini; Claudia Piutti; Francesca Quartieri; Alessandra Scolaro; Gianluca Papeo
Journal:  Mar Drugs       Date:  2009-11-27       Impact factor: 5.118
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