BACKGROUND: Although there is evidence that contact with mice is associated with IgE-mediated mouse sensitization and mouse specific antibody responses, the exposure-response relationships remain unclear. OBJECTIVE: To determine whether IgE-mediated mouse sensitization and mouse specific IgG (mIgG) and mIgG4 levels increase with increasing Mus m 1 exposure. METHODS: One hundred fifty-one workers at a mouse research and production facility were studied. Exposure assignments were made by linking participants to airborne Mus m 1 concentrations in their respective work areas. Cumulative exposure was estimated by multiplying airborne Mus m 1 concentration by duration of employment. Serum mIgG and mIgG4 levels were quantified by antigen-binding assays, and IgE-mediated mouse sensitization was evaluated by skin prick testing (SPT). RESULTS: Prevalence rates of mouse SPT sensitivity and of high levels of mIgG and mIgG4 were increasingly higher by quintiles of increasing cumulative exposure (P < .01 for SPT, mIgG, and mIgG4). After adjusting for age, sex, and atopy, the log odds ratio (OR) of having positive mouse SPT results was linearly related to cumulative exposure (r2 = 0.87), as was the log OR of having a high mIgG level (r2 = 0.86). Quintile of cumulative exposure was an independent predictor of both SPT sensitivity (OR, 1.7; 95% confidence interval, 1.2-2.5) and a high mIgG level (OR, 1.7; 95% confidence interval, 1.2-2.4). CONCLUSIONS: IgE-mediated mouse sensitization and mIgG and mIgG4 levels were related to cumulative exposure in a dose-dependent manner. Thus, strategies to prevent allergy to mice should remain focused on reducing mouse allergen exposure.
BACKGROUND: Although there is evidence that contact with mice is associated with IgE-mediated mouse sensitization and mouse specific antibody responses, the exposure-response relationships remain unclear. OBJECTIVE: To determine whether IgE-mediated mouse sensitization and mouse specific IgG (mIgG) and mIgG4 levels increase with increasing Mus m 1 exposure. METHODS: One hundred fifty-one workers at a mouse research and production facility were studied. Exposure assignments were made by linking participants to airborne Mus m 1 concentrations in their respective work areas. Cumulative exposure was estimated by multiplying airborne Mus m 1 concentration by duration of employment. Serum mIgG and mIgG4 levels were quantified by antigen-binding assays, and IgE-mediated mouse sensitization was evaluated by skin prick testing (SPT). RESULTS: Prevalence rates of mouse SPT sensitivity and of high levels of mIgG and mIgG4 were increasingly higher by quintiles of increasing cumulative exposure (P < .01 for SPT, mIgG, and mIgG4). After adjusting for age, sex, and atopy, the log odds ratio (OR) of having positive mouse SPT results was linearly related to cumulative exposure (r2 = 0.87), as was the log OR of having a high mIgG level (r2 = 0.86). Quintile of cumulative exposure was an independent predictor of both SPT sensitivity (OR, 1.7; 95% confidence interval, 1.2-2.5) and a high mIgG level (OR, 1.7; 95% confidence interval, 1.2-2.4). CONCLUSIONS: IgE-mediated mouse sensitization and mIgG and mIgG4 levels were related to cumulative exposure in a dose-dependent manner. Thus, strategies to prevent allergy to mice should remain focused on reducing mouse allergen exposure.
Authors: Jill Berg; Rob McConnell; Joel Milam; Judith Galvan; Jenny Kotlerman; Peter Thorne; Craig Jones; Ronald Ferdman; Peyton Eggleston; Cynthia Rand; Mary Ann Lewis; John Peters; Jean Richardson Journal: J Urban Health Date: 2007-11-15 Impact factor: 3.671
Authors: Esmeralda J M Krop; Gert Doekes; Martin J Stone; Rob C Aalberse; Jaring S van der Zee Journal: Occup Environ Med Date: 2006-10-19 Impact factor: 4.402
Authors: Roger D Peng; Beverly Paigen; Peyton A Eggleston; Karol A Hagberg; Mary Krevans; Jean Curtin-Brosnan; Cristy Benson; Wayne G Shreffler; Elizabeth C Matsui Journal: J Allergy Clin Immunol Date: 2011-06-22 Impact factor: 10.793
Authors: Wanda Phipatanakul; Elizabeth Matsui; Jay Portnoy; P Brock Williams; Charles Barnes; Kevin Kennedy; David Bernstein; Joann Blessing-Moore; Linda Cox; David Khan; David Lang; Richard Nicklas; John Oppenheimer; Christopher Randolph; Diane Schuller; Sheldon Spector; Stephen A Tilles; Dana Wallace; James Sublett; Jonathan Bernstein; Carl Grimes; J David Miller; James Seltzer Journal: Ann Allergy Asthma Immunol Date: 2012-12 Impact factor: 6.347