Literature DB >> 15325729

Neutralization potential of Viper russelli russelli (Russell's viper) venom by ethanol leaf extract of Acalypha indica.

Annie Shirwaikar1, K Rajendran, Ramgopal Bodla, C Dinesh Kumar.   

Abstract

The study aims to examine the Viper russelli russelli venom neutralization potential of the ethanol leaf extract (250, 500 and 750 mg/kg) of Acalypha indica (Euphorbiaceae). Administration of the ethanol leaf extract at i.p. dose levels of 500 and 750 mg/kg significantly inhibited, in a dose dependent manner, the Viper russelli venom-induced lethality, haemorrhage, necrotizing and mast cell degranulation in rats and the cardiotoxic and neurotoxic effects in isolated frog tissue. Administration of the extract also significantly inhibited venom-induced lipid peroxidation in RBC, decreased GSH and catalase levels of rat kidney tissue. The observations confirmed that the ethanol leaf extract of Acalypha indica possesses potent snake venom neutralizing properties.

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Year:  2004        PMID： 15325729     DOI： 10.1016/j.jep.2004.05.010

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN： 0378-8741            Impact factor:   4.360


  9 in total

1.  Antivenom potential of ethanolic extract of Cordia macleodii bark against Naja venom.

Authors:  Pranay Soni; Surendra H Bodakhe
Journal:  Asian Pac J Trop Biomed       Date:  2014-05

2.  Therapeutic application of natural inhibitors against snake venom phospholipase A(2).

Authors:  Ramar Perumal Samy; Ponnampalam Gopalakrishnakone; Vincent Tk Chow
Journal:  Bioinformation       Date:  2012-01-06

3.  Do herbal medicines have potential for managing snake bite envenomation?

Authors:  Y K Gupta; S S Peshin
Journal:  Toxicol Int       Date:  2012-05

4.  Ethnopharmacological survey of medicinal plants used by traditional healers and indigenous people in chittagong hill tracts, bangladesh, for the treatment of snakebite.

Authors:  Mohammad Fahim Kadir; James Regun Karmoker; Md Rashedul Alam; Syeda Rawnak Jahan; Sami Mahbub; M M K Mia
Journal:  Evid Based Complement Alternat Med       Date:  2015-03-23       Impact factor: 2.629

5.  Postprandial Antihyperglycemic And Antioxidant Activities of Acalypha indica Linn Stem Extract: An In-vivo Study.

Authors:  Charles Lekhya Priya; K V Bhaskara Rao
Journal:  Pharmacogn Mag       Date:  2016-07       Impact factor: 1.085

6.  Antimicrobial Mechanism and Identification of the Proteins Mediated by Extracts from Asphaltum punjabianum and Myrtus communis.

Authors:  Kawther Aabed; Afrah E Mohammed; Hicham Benabdelkamel; Afshan Masood; Assim A Alfadda; Ibrahim O Alanazi; Eman A Alnehmi
Journal:  ACS Omega       Date:  2020-11-23

7.  In Vitro and In Vivo Evaluation of Polyherbal Formulation against Russell's Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies.

Authors:  G Sakthivel; Amitabha Dey; Kh Nongalleima; Murthy Chavali; R S Rimal Isaac; N Surjit Singh; Lokesh Deb
Journal:  Evid Based Complement Alternat Med       Date:  2013-02-28       Impact factor: 2.629

8.  Phytochemical analysis, antimicrobial and radical-scavenging properties of Acalypha manniana leaves.

Authors:  Jaures Ak Noumedem; Jean de Dieu Tamokou; Gerald Ngo Teke; Rosine Cd Momo; Victor Kuete; Jules Roger Kuiate
Journal:  Springerplus       Date:  2013-10-03

Review 9.  Medicinal Plants for the Treatment of Local Tissue Damage Induced by Snake Venoms: An Overview from Traditional Use to Pharmacological Evidence.

Authors:  Juliana Félix-Silva; Arnóbio Antônio Silva-Junior; Silvana Maria Zucolotto; Matheus de Freitas Fernandes-Pedrosa
Journal:  Evid Based Complement Alternat Med       Date:  2017-08-21       Impact factor: 2.629
  9 in total

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