Literature DB >> 15325716

Medical aspects of biologic toxins.

James D Marks1.   

Abstract

Biologic toxins are molecules produced by living organisms that are poisonous to other species, such as humans. Some biologic toxins are so potent and relatively easy to produce that they have been classified as biothreat agents. These include the botulinum neurotoxins, ricin, staphylococcal enterotoxin B, and Clostridium perfringens epsilon toxin. This article focuses on these four biothreat toxins and their medical aspects. The majority of the article is spent on the botulinum neurotoxins, because these are the most poisonous substances known and are the only toxins classified as Category A threat agents-the highest level of threat agent. The remainder of the article is devoted to sections on the other three biothreat toxins: ricin, staphylococcal enterotoxin B, and C perfringens epsilon toxin.

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Year:  2004        PMID: 15325716     DOI: 10.1016/j.atc.2004.05.010

Source DB:  PubMed          Journal:  Anesthesiol Clin North Am        ISSN: 0889-8537


  9 in total

Review 1.  Obstructing toxin pathways by targeted pore blockage.

Authors:  Ekaterina M Nestorovich; Sergey M Bezrukov
Journal:  Chem Rev       Date:  2012-10-11       Impact factor: 60.622

2.  Polymer partitioning and ion selectivity suggest asymmetrical shape for the membrane pore formed by epsilon toxin.

Authors:  Ekaterina M Nestorovich; Vladimir A Karginov; Sergey M Bezrukov
Journal:  Biophys J       Date:  2010-08-04       Impact factor: 4.033

3.  Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors.

Authors:  Bing Li; Steven C Cardinale; Michelle M Butler; Ramdas Pai; Jonathan E Nuss; Norton P Peet; Sina Bavari; Terry L Bowlin
Journal:  Bioorg Med Chem       Date:  2011-10-26       Impact factor: 3.641

4.  Perturbation to Cholesterol at the Neuromuscular Junction Confers Botulinum Neurotoxin A Sensitivity to Neonatal Mice.

Authors:  Baskaran Thyagarajan; Joseph G Potian; Joseph J McArdle; Padmamalini Baskaran
Journal:  Toxicol Sci       Date:  2017-09-01       Impact factor: 4.849

5.  Biocrimes, microbial forensics, and the physician.

Authors:  Steven E Schutzer; Bruce Budowle; Ronald M Atlas
Journal:  PLoS Med       Date:  2005-09-27       Impact factor: 11.069

6.  Monoclonal Antibodies Targeting the Alpha-Exosite of Botulinum Neurotoxin Serotype/A Inhibit Catalytic Activity.

Authors:  Yongfeng Fan; Isin N Geren; Jianbo Dong; Jianlong Lou; Weihua Wen; Fraser Conrad; Theresa J Smith; Leonard A Smith; Mengfei Ho; Melissa Pires-Alves; Brenda A Wilson; James D Marks
Journal:  PLoS One       Date:  2015-08-14       Impact factor: 3.240

Review 7.  Toxins as biological weapons for terror-characteristics, challenges and medical countermeasures: a mini-review.

Authors:  Tamar Berger; Arik Eisenkraft; Erez Bar-Haim; Michael Kassirer; Adi Avniel Aran; Itay Fogel
Journal:  Disaster Mil Med       Date:  2016-04-29

Review 8.  Small molecule inhibitors as countermeasures for botulinum neurotoxin intoxication.

Authors:  Bing Li; Norton P Peet; Michelle M Butler; James C Burnett; Donald T Moir; Terry L Bowlin
Journal:  Molecules       Date:  2010-12-30       Impact factor: 4.411

9.  Llama single domain antibodies specific for the 7 botulinum neurotoxin serotypes as heptaplex immunoreagents.

Authors:  Jerry O Conway; Laura J Sherwood; M Thelma Collazo; John A Garza; Andrew Hayhurst
Journal:  PLoS One       Date:  2010-01-21       Impact factor: 3.240

  9 in total

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