Thomas D Giles1, Thomas D Robinson. 1. Division of Cardiology, Louisiana State University School of Medicine, New Orleans 70112, USA. tgiles@lsumc.edu
Abstract
BACKGROUND: In this analysis, we evaluated the efficacy of the angiotensin II receptor blocker olmesartan medoxomil in reducing systolic blood pressure (SBP) and pulse pressure (PP) in hypertensive patients. METHODS: Data from seven randomized, double blind, placebo controlled, 6- to 12-week efficacy trials of olmesartan 20 mg and 40 mg/day were analyzed to determine changes in trough seated SBP and PP within three cohorts: 1) total cohort (n = 1777); 2) subjects with a wide PP: that is, those with a baseline PP >55 mm Hg (n = 917); and 3) a subpopulation of patients with a wide PP and age > or = 65 years (n = 296). Statistical comparisons used least squares mean values. RESULTS: In the total cohort, olmesartan 20 and 40 mg/day resulted in mean reductions in SBP of 15.1 and 17.6 mm Hg, respectively (P < .001 v placebo). In the wide PP cohort, olmesartan resulted in mean reductions in SBP of 17.7 and 22.0 mm Hg and mean reductions in PP of 7.4 Hg and 8.8 mm Hg for the groups receiving 20 and 40 mg/day, respectively (P < .001 v placebo). In the cohort with wide PP and age > or = 65 years, olmesartan 20 and 40 mg/day produced mean reductions in SBP of 21.8 and 22.5 mm Hg, and PP of 6.7 and 7.6 mm Hg, respectively (P < .05 v placebo). CONCLUSIONS:Olmesartan significantly reduces SBP and PP, and these reductions are more pronounced in patients with a wide baseline PP. In patients with a wide baseline PP and age > or = 65 years, the population at greatest risk for cardiovascular morbidity and mortality, olmesartan reduces PP to an extent similar to that in patients <65 years of age. Copyright 2004 American Journal of Hypertension, Ltd.
RCT Entities:
BACKGROUND: In this analysis, we evaluated the efficacy of the angiotensin II receptor blocker olmesartanmedoxomil in reducing systolic blood pressure (SBP) and pulse pressure (PP) in hypertensivepatients. METHODS: Data from seven randomized, double blind, placebo controlled, 6- to 12-week efficacy trials of olmesartan 20 mg and 40 mg/day were analyzed to determine changes in trough seated SBP and PP within three cohorts: 1) total cohort (n = 1777); 2) subjects with a wide PP: that is, those with a baseline PP >55 mm Hg (n = 917); and 3) a subpopulation of patients with a wide PP and age > or = 65 years (n = 296). Statistical comparisons used least squares mean values. RESULTS: In the total cohort, olmesartan 20 and 40 mg/day resulted in mean reductions in SBP of 15.1 and 17.6 mm Hg, respectively (P < .001 v placebo). In the wide PP cohort, olmesartan resulted in mean reductions in SBP of 17.7 and 22.0 mm Hg and mean reductions in PP of 7.4 Hg and 8.8 mm Hg for the groups receiving 20 and 40 mg/day, respectively (P < .001 v placebo). In the cohort with wide PP and age > or = 65 years, olmesartan 20 and 40 mg/day produced mean reductions in SBP of 21.8 and 22.5 mm Hg, and PP of 6.7 and 7.6 mm Hg, respectively (P < .05 v placebo). CONCLUSIONS:Olmesartan significantly reduces SBP and PP, and these reductions are more pronounced in patients with a wide baseline PP. In patients with a wide baseline PP and age > or = 65 years, the population at greatest risk for cardiovascular morbidity and mortality, olmesartan reduces PP to an extent similar to that in patients <65 years of age. Copyright 2004 American Journal of Hypertension, Ltd.
Authors: Vivencio Barrios; Alessandro Boccanelli; Silke Ewald; Xavier Girerd; Anthony Heagerty; Jean-Marie Krzesinski; Robert Lins; José Rodicio; Thomas Stefenelli; Arend Woittiez; Michael Böhm Journal: Clin Drug Investig Date: 2007 Impact factor: 2.859