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Literature DB >> 15322817

[Chemotherapy-induced changes in high grade central osteosarcomas-experiences gained through the assignment as reference-pathologists of the COSS-studies].

Abstract

High-grade central osteosarcomas are the most frequent malignant bone neoplasms in childhood and adolescence. Their prognosis has been substantially improved using neoadjuvant chemotherapy. The morphological examination of surgical specimens reveals important information regarding the success of treatment. The histological determined degree of regression represents one of the most reliable therapy-related prognostical factor. Thus pathological analysis of the surgical specimens is of great importance notwithstanding the improved clinical and radiological diagnostic of osteosarcoma.

Entities: Disease

Mesh：

Substances：
Antineoplastic Agents

Year: 2004 PMID： 15322817 DOI： 10.1007/s00292-004-0712-7

Source DB: PubMed Journal: Pathologe ISSN： 0172-8113 Impact factor: 1.011

26 in total

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Authors: B Jobke; M Werner
Journal: Radiologe Date: 2016-06 Impact factor: 0.635

2 in total