Literature DB >> 15322050

The AraC family transcriptional regulator Rv1931c plays a role in the virulence of Mycobacterium tuberculosis.

Cristiane C Frota1, K G Papavinasasundaram, Elaine O Davis, M Joseph Colston.   

Abstract

A Mycobacterium tuberculosis strain disrupted in the AraC homologue Rv1931c was isolated. The mutant strain exhibited reduced survival both in macrophages and in a mouse infection model, with survival being restored on complementation with the Rv1931c gene. These results suggest that Rv1931c regulates genes important for virulence of M. tuberculosis.

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Year:  2004        PMID： 15322050      PMCID： PMC517439          DOI： 10.1128/IAI.72.9.5483-5486.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  19 in total

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