Literature DB >> 1532126

Apolipoprotein (a) alleles determine lipoprotein (a) particle density and concentration in plasma.

H G Kraft1, C Sandholzer, H J Menzel, G Utermann.   

Abstract

The distribution of Lp(a) lipoprotein (Lp[a]) and genetic apolipoprotein(a) (apo[a]) isoforms in plasma samples from 29 healthy normolipidemic subjects of known apo(a) phenotype was evaluated by density gradient ultracentrifugation. The density of Lp(a) was directly related to the size of the apo(a) isoform, ranging from 1.043 g/ml for the LpF phenotype to 1.114 g/ml for the LpS4 phenotype. Heterozygotes had two distinct Lp(a) particles, each containing one of the respective isoforms in plasma. In each heterozygote, the concentration of the lighter Lp(a) species was higher than that of the denser Lp(a) population. These data suggest that apo(a) alleles determine the density and the metabolism and thereby also the concentrations of Lp(a) particles in plasma.

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Year:  1992        PMID： 1532126     DOI： 10.1161/01.atv.12.3.302

Source DB:  PubMed          Journal:  Arterioscler Thromb        ISSN： 1049-8834


  13 in total

1.  Distribution of apolipoprotein(a) in the plasma from patients with lipoprotein lipase deficiency and with type III hyperlipoproteinemia. No evidence for a triglyceride-rich precursor of lipoprotein(a).

Authors:  C Sandholzer; G Feussner; J Brunzell; G Utermann
Journal:  J Clin Invest       Date:  1992-11       Impact factor: 14.808

Review 2.  Structure, function, and genetics of lipoprotein (a).

Authors:  Konrad Schmidt; Asma Noureen; Florian Kronenberg; Gerd Utermann
Journal:  J Lipid Res       Date:  2016-04-13       Impact factor: 5.922

Review 3.  Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology.

Authors:  Børge G Nordestgaard; Anne Langsted
Journal:  J Lipid Res       Date:  2016-09-27       Impact factor: 5.922

4.  Clinical and genetic features in a family with CADASIL and high lipoprotein (a) values.

Authors:  Maolian Gong; Franz Rueschendorf; Peter Marx; Herbert Schulz; Hans-Georg Kraft; Norbert Huebner; Hans-Christian Koennecke
Journal:  J Neurol       Date:  2010-02-09       Impact factor: 4.849

Review 5.  Lipoprotein(a) and the atherothrombotic process: mechanistic insights and clinical implications.

Authors:  Angelo M Scanu
Journal:  Curr Atheroscler Rep       Date:  2003-03       Impact factor: 5.113

6.  The inverse association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform size is not due to differences in Lp(a) catabolism but to differences in production rate.

Authors:  D J Rader; W Cain; K Ikewaki; G Talley; L A Zech; D Usher; H B Brewer
Journal:  J Clin Invest       Date:  1994-06       Impact factor: 14.808

7.  The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration.

Authors:  H G Kraft; S Köchl; H J Menzel; C Sandholzer; G Utermann
Journal:  Hum Genet       Date:  1992-11       Impact factor: 4.132

8.  Effects of mipomersen, an apolipoprotein B100 antisense, on lipoprotein (a) metabolism in healthy subjects.

Authors:  Renu Nandakumar; Anastasiya Matveyenko; Tiffany Thomas; Marianna Pavlyha; Colleen Ngai; Stephen Holleran; Rajasekhar Ramakrishnan; Henry N Ginsberg; Wahida Karmally; Santica M Marcovina; Gissette Reyes-Soffer
Journal:  J Lipid Res       Date:  2018-10-07       Impact factor: 5.922

Review 9.  Genetics of Lipoprotein(a): Cardiovascular Disease and Future Therapy.

Authors:  Anne Langsted; Børge G Nordestgaard
Journal:  Curr Atheroscler Rep       Date:  2021-06-20       Impact factor: 5.113

10.  Sequence polymorphism in kringle IV 37 in linkage disequilibrium with the apolipoprotein (a) size polymorphism.

Authors:  H G Kraft; C Haibach; A Lingenhel; C Brunner; M Trommsdorff; F Kronenberg; H J Müller; G Utermann
Journal:  Hum Genet       Date:  1995-03       Impact factor: 4.132
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