Literature DB >> 15318805

Nutrient-gene interactions: a single nutrient and hundreds of target genes.

Hannelore Daniel1, Heike tom Dieck.   

Abstract

Based on the effects of a selective experimental zinc deficiency in a rodent model we explore the use of transcriptome profiling for assessing nutrient-gene interactions in the liver at the molecular and cellular levels. Zinc deficiency caused pleiotropic alterations in mRNA/protein levels of hundreds of genes. In the context of observed metabolic alterations in hepatic metabolism, possible mechanisms are discussed for how a low zinc status may be sensed and transmitted into changes in various metabolic pathways. However, it also becomes obvious that analysis of such complex nutrient-gene interactions beyond the descriptional level is a real challenge for systems biology.

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Year:  2004        PMID： 15318805     DOI： 10.1515/BC.2004.071

Source DB:  PubMed          Journal:  Biol Chem        ISSN： 1431-6730            Impact factor:   3.915


  6 in total

1.  Reaction of metal-binding ligands with the zinc proteome: zinc sensors and N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine.

Authors:  Jeffrey W Meeusen; Andrew Nowakowski; David H Petering
Journal:  Inorg Chem       Date:  2012-03-01       Impact factor: 5.165

2.  High-fat diet leads to tissue-specific changes reflecting risk factors for diseases in DBA/2J mice.

Authors:  Rachael S Hageman; Asja Wagener; Claudia Hantschel; Karen L Svenson; Gary A Churchill; Gudrun A Brockmann
Journal:  Physiol Genomics       Date:  2010-03-09       Impact factor: 3.107

3.  Chemopreventive effects of zinc on prostate carcinogenesis induced by N-methyl-N-nitrosourea and testosterone in adult male Sprague-Dawley rats.

Authors:  S Banudevi; P Elumalai; R Arunkumar; K Senthilkumar; D N Gunadharini; G Sharmila; J Arunakaran
Journal:  J Cancer Res Clin Oncol       Date:  2010-06-16       Impact factor: 4.553

4.  BIOCLAIMS standard diet (BIOsd): a reference diet for nutritional physiology.

Authors:  Femke P M Hoevenaars; Evert M van Schothorst; Olga Horakova; Anja Voigt; Martin Rossmeisl; Catalina Pico; Antoni Caimari; Jan Kopecky; Susanne Klaus; Jaap Keijer
Journal:  Genes Nutr       Date:  2012-01-07       Impact factor: 5.523

5.  Differential gene expression after zinc supplementation and deprivation in human leukocyte subsets.

Authors:  Hajo Haase; Dawn J Mazzatti; Andrew White; Klaus H Ibs; Gabriela Engelhardt; Silke Hebel; Jonathan R Powell; Lothar Rink
Journal:  Mol Med       Date:  2007 Jul-Aug       Impact factor: 6.354

6.  Alterations in Intestinal Brush Border Membrane Functionality and Bacterial Populations Following Intra-Amniotic Administration (Gallus gallus) of Catechin and Its Derivatives.

Authors:  Nikolai Kolba; Amin Zarei; Jacquelyn Cheng; Nikita Agarwal; Younas Dadmohammadi; Leila Khazdooz; Alireza Abbaspourrad; Elad Tako
Journal:  Nutrients       Date:  2022-09-22       Impact factor: 6.706
  6 in total

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