Literature DB >> 15318402

A novel cytotoxic oxetane ent-kauranoid from Isodon japonicus.

Quanbin Han1, Jixia Zhang, Yang Lu, Yunshan Wu, Qitai Zheng, Handong Sun.   

Abstract

A novel ll,20: 1,20-diepoxy-ent-kaurane diterpenoid, maoyecrystal 1 (1), was isolated from Isodan japonicus, and its structure was elucidated by spectroscopic methods and comparison with another new ent-kauranoid, rubescensin W (2) from Isodon rubescens var. taihangensis. The structure of 2 was determined by single crystal X-ray diffraction analysis. A bioassay of their cytotoxity against K562 cells showed that the oxetane group of 1 might be a bioactive moiety.

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Year:  2004        PMID: 15318402     DOI: 10.1055/s-2004-827165

Source DB:  PubMed          Journal:  Planta Med        ISSN: 0032-0943            Impact factor:   3.352


  2 in total

1.  Phytotoxic effects of leukamenin E (an ent-kaurene diterpenoid) on root growth and root hair development in Lactuca sativa L. seedlings.

Authors:  Lan Ding; Linlin Qi; Hongwei Jing; Juan Li; Wei Wang; Tao Wang
Journal:  J Chem Ecol       Date:  2008-10-21       Impact factor: 2.626

2.  Synthetic, Mechanistic, and Biological Interrogation of Ginkgo biloba Chemical Space En Route to (-)-Bilobalide.

Authors:  Robert M Demoret; Meghan A Baker; Masaki Ohtawa; Shuming Chen; Ching Ching Lam; Sophia Khom; Marisa Roberto; Stefano Forli; Kendall N Houk; Ryan A Shenvi
Journal:  J Am Chem Soc       Date:  2020-10-16       Impact factor: 15.419

  2 in total

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