BACKGROUND: The aim of the present study was to investigate the effect of N-acetylcysteine on intestinal reperfusion injury. METHODS: Forty Sprague-Dawley rats were divided into four groups (n = 10): sham, sham + N-acetylcysteine, reperfusion, and reperfusion + N-acetylcysteine. Thirty minutes of ischaemia +/- 30 min of reperfusion was performed under 100 mg/kg N-acetylcysteine or placebo, administered 30 min before the operation in the groups where appropriate. Ileum samples were resected for histopathologic evaluation and tissue malondialdehyde and super oxide dismutase level determination. RESULTS: The mean mucosal injury score and malondialdehyde level of the reperfusion and reperfusion + N-acetylcysteine groups were significantly higher than that of the control and control + N-acetylcysteine group (P < 0.01, P < 0.05, respectively). Mean super oxide dismutase level of the control + N-acetylcysteine group was significantly higher than that of the other groups (P < 0.05). CONCLUSION: N-Acetylcysteine did not prevent intestinal reperfusion injury by means of histopathologic findings and malondialdehyde level.
BACKGROUND: The aim of the present study was to investigate the effect of N-acetylcysteine on intestinal reperfusion injury. METHODS: Forty Sprague-Dawley rats were divided into four groups (n = 10): sham, sham + N-acetylcysteine, reperfusion, and reperfusion + N-acetylcysteine. Thirty minutes of ischaemia +/- 30 min of reperfusion was performed under 100 mg/kg N-acetylcysteine or placebo, administered 30 min before the operation in the groups where appropriate. Ileum samples were resected for histopathologic evaluation and tissue malondialdehyde and super oxide dismutase level determination. RESULTS: The mean mucosal injury score and malondialdehyde level of the reperfusion and reperfusion + N-acetylcysteine groups were significantly higher than that of the control and control + N-acetylcysteine group (P < 0.01, P < 0.05, respectively). Mean super oxide dismutase level of the control + N-acetylcysteine group was significantly higher than that of the other groups (P < 0.05). CONCLUSION:N-Acetylcysteine did not prevent intestinal reperfusion injury by means of histopathologic findings and malondialdehyde level.
Authors: A E Gordeeva; A A Temnov; A A Charnagalov; M G Sharapov; E E Fesenko; V I Novoselov Journal: Dig Dis Sci Date: 2015-08-02 Impact factor: 3.199
Authors: Soraia Guerra Silvares; Antonio Fernandes Moron; Manuel de Jesus Simões; Álvaro Ulhoa Cintra; Edna Frasson de Souza Montero; Edward Araujo Júnior; José Luiz Martins Journal: Acta Cir Bras Date: 2020-06-05 Impact factor: 1.388