Literature DB >> 15315451

A new approach to natural products discovery exemplified by the identification of sulfated nucleosides in spider venom.

Andrew E Taggi1, Jerrold Meinwald, Frank C Schroeder.   

Abstract

Using a new approach based on the NMR spectroscopic analysis of the entire, unpurified spider venom, we identified a family of unusual sulfated nucleoside derivatives from the venom of the hobo spider, Tegenaria agrestis. These compounds are ribonucleoside mono- and disulfates derived from guanosine and xanthosine, some of which are glycosylated, bearing one or two D-fucose units. The use of NMR spectroscopy to characterize the unfractionated venom was central to the discovery of this heretofore overlooked class of venom components.

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Year:  2004        PMID： 15315451     DOI： 10.1021/ja047416n

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  23 in total

Review 1.  NMR-spectroscopic analysis of mixtures: from structure to function.

Authors:  Ry R Forseth; Frank C Schroeder
Journal:  Curr Opin Chem Biol       Date:  2010-11-09       Impact factor: 8.822

2.  Identification of xanthurenic acid 8-O-beta-D-glucoside and xanthurenic acid 8-O-sulfate as human natriuretic hormones.

Authors:  Christopher D Cain; Frank C Schroeder; Stewart W Shankel; Mark Mitchnick; Michael Schmertzler; Neal S Bricker
Journal:  Proc Natl Acad Sci U S A       Date:  2007-10-31       Impact factor: 11.205

3.  Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis.

Authors:  Ry R Forseth; Ellen M Fox; DaWoon Chung; Barbara J Howlett; Nancy P Keller; Frank C Schroeder
Journal:  J Am Chem Soc       Date:  2011-06-06       Impact factor: 15.419

4.  Nematode signaling molecules derived from multimodular assembly of primary metabolic building blocks.

Authors:  Joshua J Yim; Neelanjan Bose; Jan M Meyer; Ralf J Sommer; Frank C Schroeder
Journal:  Org Lett       Date:  2015-03-18       Impact factor: 6.005

5.  2D NMR-spectroscopic screening reveals polyketides in ladybugs.

Authors:  Stephen T Deyrup; Laura E Eckman; Patrick H McCarthy; Scott R Smedley; Jerrold Meinwald; Frank C Schroeder
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-06       Impact factor: 11.205

6.  Pinoresinol: A lignol of plant origin serving for defense in a caterpillar.

Authors:  Frank C Schroeder; Marta L del Campo; Jacqualine B Grant; Douglas B Weibel; Scott R Smedley; Kelly L Bolton; Jerrold Meinwald; Thomas Eisner
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-09       Impact factor: 11.205

7.  Antineoplastic agents. 573. isolation and structure of papilistatin from the papilionid butterfly Byasa polyeuctes termessa.

Authors:  George R Pettit; Qinghua Ye; Delbert L Herald; Fiona Hogan; Robin K Pettit
Journal:  J Nat Prod       Date:  2010-02-26       Impact factor: 4.050

8.  Correlating secondary metabolite production with genetic changes using differential analysis of 2D NMR spectra.

Authors:  Ry R Forseth; Frank C Schroeder
Journal:  Methods Mol Biol       Date:  2012

9.  Dietary sequestration of defensive steroids in nuchal glands of the Asian snake Rhabdophis tigrinus.

Authors:  Deborah A Hutchinson; Akira Mori; Alan H Savitzky; Gordon M Burghardt; Xiaogang Wu; Jerrold Meinwald; Frank C Schroeder
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-06       Impact factor: 11.205

10.  NMR-spectroscopic screening of spider venom reveals sulfated nucleosides as major components for the brown recluse and related species.

Authors:  Frank C Schroeder; Andrew E Taggi; Matthew Gronquist; Rabia U Malik; Jacqualine B Grant; Thomas Eisner; Jerrold Meinwald
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-15       Impact factor: 11.205
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