OBJECTIVE: The objective of this study was to evaluate the diagnostic accuracy of Tc-99m-labeled antigranulocyte antibody Fab' fragments in infected total arthroplasty. MATERIALS AND METHODS: A total of 38 immunoscintigrams were evaluated retrospectively with 15 to 25 mCi Tc-99m-labeled antigranulocyte antibody-Fab' fragments. The final diagnosis was assessed by articular puncture or intraoperative sampling. RESULTS: In the total hip replacement group the authors found 10 true positives, 7 true negatives, 8 false positives, and 1 false negative; and in the total knee replacement group they found 4 true positives, 8 true negatives, and no false positives or false negatives. They also found a sensitivity of 93%, a specificity of 65%, and a positive predictive accuracy of 63%. There was a negative predictive accuracy of 94%. CONCLUSION: The high negative predictive accuracy in the whole group suggests that the scan can be used to exclude infection in most cases. Negative results with a high clinical suspicion merits further investigation. A positive result will require further correlative imaging, especially for total knee replacement.
OBJECTIVE: The objective of this study was to evaluate the diagnostic accuracy of Tc-99m-labeled antigranulocyte antibody Fab' fragments in infected total arthroplasty. MATERIALS AND METHODS: A total of 38 immunoscintigrams were evaluated retrospectively with 15 to 25 mCi Tc-99m-labeled antigranulocyte antibody-Fab' fragments. The final diagnosis was assessed by articular puncture or intraoperative sampling. RESULTS: In the total hip replacement group the authors found 10 true positives, 7 true negatives, 8 false positives, and 1 false negative; and in the total knee replacement group they found 4 true positives, 8 true negatives, and no false positives or false negatives. They also found a sensitivity of 93%, a specificity of 65%, and a positive predictive accuracy of 63%. There was a negative predictive accuracy of 94%. CONCLUSION: The high negative predictive accuracy in the whole group suggests that the scan can be used to exclude infection in most cases. Negative results with a high clinical suspicion merits further investigation. A positive result will require further correlative imaging, especially for total knee replacement.
Authors: Vera Graute; Markus Feist; Sebastian Lehner; Alexander Haug; Peter Ernst Müller; Peter Bartenstein; Marcus Hacker Journal: Eur J Nucl Med Mol Imaging Date: 2010-03-23 Impact factor: 9.236
Authors: Steven J Verberne; Remko J A Sonnega; Olivier P P Temmerman; Pieter G Raijmakers Journal: Clin Orthop Relat Res Date: 2017-01-03 Impact factor: 4.176