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Literature DB >> 15310845

Evidence for conformational coupling between two calcium channels.

C Paolini¹, James D Fessenden, Isaac N Pessah, C Franzini-Armstrong.

Abstract

Ryanodine receptor 1 (RyR1, the sarcoplasmic reticulum Ca(2+) release channel) and alpha(1S)dihydropyridine receptor (DHPR, the surface membrane voltage sensor) of skeletal muscle belong to separate membrane systems but are functionally and structurally linked. Four alpha(1S)DHPRs associated with the four identical subunits of a RyR form a tetrad. We treated skeletal muscle cell lines with ryanodine, at concentrations that block RyRs, and determined whether this treatment affects the distance between DHPRs in the tetrad. We find a substantial ( approximately 2-nm) shift in the alpha(1S)DHPR positions, indicating that ryanodine induces large conformational changes in the RyR1 cytoplasmic domain and that the alpha(1S)DHPR-RyR complex acts as a unit.

Entities: Chemical Gene

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Year: 2004 PMID： 15310845 PMCID： PMC515124 DOI： 10.1073/pnas.0404836101

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

39 in total

1. Involvement of the carboxy-terminus region of the dihydropyridine receptor beta1a subunit in excitation-contraction coupling of skeletal muscle.

Authors: M Beurg; C A Ahern; P Vallejo; M W Conklin; P A Powers; R G Gregg; R Coronado
Journal: Biophys J Date: 1999-12 Impact factor: 4.033

2. The Croonian Lecture 2000. Nicotinic acetylcholine receptor and the structural basis of fast synaptic transmission.

Authors: N Unwin
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2000-12-29 Impact factor: 6.237

3. Electron cryomicroscopy and angular reconstitution used to visualize the skeletal muscle calcium release channel.

Authors: I I Serysheva; E V Orlova; W Chiu; M B Sherman; S L Hamilton; M van Heel
Journal: Nat Struct Biol Date: 1995-01

4. Restoration of junctional tetrads in dysgenic myotubes by dihydropyridine receptor cDNA.

Authors: H Takekura; L Bennett; T Tanabe; K G Beam; C Franzini-Armstrong
Journal: Biophys J Date: 1994-08 Impact factor: 4.033

5. Ryanodine receptor point mutant E4032A reveals an allosteric interaction with ryanodine.

Authors: J D Fessenden; L Chen; Y Wang; C Paolini; C Franzini-Armstrong; P D Allen; I N Pessah
Journal: Proc Natl Acad Sci U S A Date: 2001-02-13 Impact factor: 11.205

6. Localization of the high and low affinity [3H]ryanodine binding sites on the skeletal muscle Ca2+ release channel.

Authors: C Callaway; A Seryshev; J P Wang; K J Slavik; D H Needleman; C Cantu; Y Wu; T Jayaraman; A R Marks; S L Hamilton
Journal: J Biol Chem Date: 1994-06-03 Impact factor: 5.157

7. Photoaffinity labeling of the ryanodine receptor/Ca2+ release channel with an azido derivative of ryanodine.

Authors: D R Witcher; P S McPherson; S D Kahl; T Lewis; P Bentley; M J Mullinnix; J D Windass; K P Campbell
Journal: J Biol Chem Date: 1994-05-06 Impact factor: 5.157

8. Three-dimensional structure of myosin subfragment-1: a molecular motor.

Authors: I Rayment; W R Rypniewski; K Schmidt-Bäse; R Smith; D R Tomchick; M M Benning; D A Winkelmann; G Wesenberg; H M Holden
Journal: Science Date: 1993-07-02 Impact factor: 47.728

9. Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor.

Authors: J Nakai; R T Dirksen; H T Nguyen; I N Pessah; K G Beam; P D Allen
Journal: Nature Date: 1996-03-07 Impact factor: 49.962

10. Cryo-electron microscopy and three-dimensional reconstruction of the calcium release channel/ryanodine receptor from skeletal muscle.

Authors: M Radermacher; V Rao; R Grassucci; J Frank; A P Timerman; S Fleischer; T Wagenknecht
Journal: J Cell Biol Date: 1994-10 Impact factor: 10.539

41 in total

10. Effects of inserting fluorescent proteins into the alpha1S II-III loop: insights into excitation-contraction coupling.

Authors: Roger A Bannister; Symeon Papadopoulos; Claudia S Haarmann; Kurt G Beam
Journal: J Gen Physiol Date: 2009-07 Impact factor: 4.086

Evidence for conformational coupling between two calcium channels.

1. Involvement of the carboxy-terminus region of the dihydropyridine receptor beta1a subunit in excitation-contraction coupling of skeletal muscle.

2. The Croonian Lecture 2000. Nicotinic acetylcholine receptor and the structural basis of fast synaptic transmission.

3. Electron cryomicroscopy and angular reconstitution used to visualize the skeletal muscle calcium release channel.

4. Restoration of junctional tetrads in dysgenic myotubes by dihydropyridine receptor cDNA.

5. Ryanodine receptor point mutant E4032A reveals an allosteric interaction with ryanodine.

6. Localization of the high and low affinity [3H]ryanodine binding sites on the skeletal muscle Ca2+ release channel.

7. Photoaffinity labeling of the ryanodine receptor/Ca2+ release channel with an azido derivative of ryanodine.

8. Three-dimensional structure of myosin subfragment-1: a molecular motor.

9. Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor.

10. Cryo-electron microscopy and three-dimensional reconstruction of the calcium release channel/ryanodine receptor from skeletal muscle.

Review 1. The role of auxiliary dihydropyridine receptor subunits in muscle.

Review 2. Ion channels and ion transporters of the transverse tubular system of skeletal muscle.

Review 3. Bridging the myoplasmic gap: recent developments in skeletal muscle excitation-contraction coupling.

4. Rem inhibits skeletal muscle EC coupling by reducing the number of functional L-type Ca2+ channels.

Review 5. Ryanodine receptor structure: progress and challenges.

6. Store-operated Ca2+ entry during intracellular Ca2+ release in mammalian skeletal muscle.

7. Quantifying SOCE fluorescence measurements in mammalian muscle fibres. The effects of ryanodine and osmotic shocks.

Review 8. New Insights in Cardiac Calcium Handling and Excitation-Contraction Coupling.

9. Ligand-dependent conformational changes in the clamp region of the cardiac ryanodine receptor.

10. Effects of inserting fluorescent proteins into the alpha1S II-III loop: insights into excitation-contraction coupling.