OBJECT: This is an investigation into the effects of two barrier membranes in the prevention of peridural fibrosis in an animal model. METHODS: Seprafilm or Gore-Tex was applied to a laminectomy defect overlying the dura mater in rats separated into treatment groups. A third group of rats underwent laminectomy only and served as controls. Two months postoperatively a histological study was performed to compare the amount of scar tissue in each group. The gross dissection demonstrated that both membranes created a controlled dissection plane, facilitated access to the epidural space, and provided a reduction in the amount of tissue adhering to the dura mater. Statistically, Seprafilm was superior to Gore-Tex in preventing peridural fibrosis (p < 0.05). CONCLUSIONS: Seprafilm can prevent peridural fibrosis better than Gore-Tex and can be used in humans in spinal surgery.
OBJECT: This is an investigation into the effects of two barrier membranes in the prevention of peridural fibrosis in an animal model. METHODS:Seprafilm or Gore-Tex was applied to a laminectomy defect overlying the dura mater in rats separated into treatment groups. A third group of rats underwent laminectomy only and served as controls. Two months postoperatively a histological study was performed to compare the amount of scar tissue in each group. The gross dissection demonstrated that both membranes created a controlled dissection plane, facilitated access to the epidural space, and provided a reduction in the amount of tissue adhering to the dura mater. Statistically, Seprafilm was superior to Gore-Tex in preventing peridural fibrosis (p < 0.05). CONCLUSIONS:Seprafilm can prevent peridural fibrosis better than Gore-Tex and can be used in humans in spinal surgery.
Authors: Ceren Kizmazoglu; Hasan Emre Aydin; Ismail Kaya; Murat Atar; Bugra Husemoglu; Orhan Kalemci; Gulden Sozer; Hasan Havitcioglu Journal: J Korean Neurosurg Soc Date: 2019-10-30