Literature DB >> 1530950

Schwannoma-derived growth factor promotes the neuronal differentiation and survival of PC12 cells.

H Kimura1, D Schubert.   

Abstract

Schwannoma-derived growth factor (SDGF) was initially isolated from schwannoma cells as a mitogen for glial cells and fibroblasts. The present data show that SDGF causes the morphological and molecular differentiation of rat PC12 cells in a manner similar to, but distinguishable from nerve growth factor (NGF). It also promotes PC12 survival in serum-free conditions. SDGF induced changes include neurite outgrowth and the induction of the mRNAs for GAP-43 and transin, proteins which are highly expressed in axons. In addition, both SDGF and NGF induce the transcription factor, NGFI-A. The time course of the response to SDGF is similar to that for NGF. Gap-43 mRNA induction by both SDGF and NGF is inhibited by dexamethasone, but dexamethasone has no effect on NGFI-A mRNA synthesis. These observations show that SDGF has a differentiation and survival promoting effect on PC12 cells in addition to its mitogenic activity on glial cells and fibroblasts.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1530950      PMCID： PMC2289303          DOI： 10.1083/jcb.116.3.777

Source DB:  PubMed          Journal:  J Cell Biol        ISSN： 0021-9525            Impact factor:   10.539


  58 in total

1.  ACTH-induced inhibition of endogenous rat brain protein phosphorylation in vitro: structure activity.

Authors:  H Zwiers; V M Wiegant; P Schotman; W H Gispen
Journal:  Neurochem Res       Date:  1978-08       Impact factor: 3.996

2.  Growth factors from murine sarcoma virus-transformed cells.

Authors:  J E de Larco; G J Todaro
Journal:  Proc Natl Acad Sci U S A       Date:  1978-08       Impact factor: 11.205

3.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

Authors:  P Chomczynski; N Sacchi
Journal:  Anal Biochem       Date:  1987-04       Impact factor: 3.365

4.  A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.

Authors:  J Milbrandt
Journal:  Science       Date:  1987-11-06       Impact factor: 47.728

5.  Specific proteolysis of a brain membrane phosphoprotein (B-50): effects of calcium and calmodulin.

Authors:  H Zwiers; W H Gispen; L Kleine; H R Mahler
Journal:  Neurochem Res       Date:  1982-02       Impact factor: 3.996

6.  Nerve growth factor is a mitogen for cultured chromaffin cells.

Authors:  L E Lillien; P Claude
Journal:  Nature       Date:  1985 Oct 17-23       Impact factor: 49.962

7.  Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

Authors:  L A Greene; A S Tischler
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205

8.  Changes in axonally transported proteins during axon regeneration in toad retinal ganglion cells.

Authors:  J H Skene; M Willard
Journal:  J Cell Biol       Date:  1981-04       Impact factor: 10.539

9.  Differential inhibition of nerve growth factor and epidermal growth factor effects on the PC12 pheochromocytoma line.

Authors:  P J Seeley; A Rukenstein; J L Connolly; L A Greene
Journal:  J Cell Biol       Date:  1984-02       Impact factor: 10.539

10.  Substratum-growth factor collaborations are required for the mitogenic activities of activin and FGF on embryonal carcinoma cells.

Authors:  D Schubert; H Kimura
Journal:  J Cell Biol       Date:  1991-08       Impact factor: 10.539
View more
  9 in total

1.  Activation of ERK1/2 and PI3K/Akt by IGF-1 on GAP-43 expression in DRG neurons with excitotoxicity induced by glutamate in vitro.

Authors:  Zhen Liu; Heng Cai; Ping Zhang; Hao Li; Huaxiang Liu; Zhenzhong Li
Journal:  Cell Mol Neurobiol       Date:  2011-08-06       Impact factor: 5.046

Review 2.  Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair.

Authors:  Dietmar M W Zaiss; William C Gause; Lisa C Osborne; David Artis
Journal:  Immunity       Date:  2015-02-17       Impact factor: 31.745

3.  Amphiregulin regulates odontogenic differentiation of dental pulp stem cells by activation of mitogen-activated protein kinase and the phosphatidylinositol 3-kinase signaling pathways.

Authors:  Junqing Li; Zhihua Wang; Juan Wang; Qian Guo; Yi Fu; Zihan Dai; Minghao Wang; Yu Bai; Xin Liu; Paul R Cooper; Jiayuan Wu; Wenxi He
Journal:  Stem Cell Res Ther       Date:  2022-07-15       Impact factor: 8.079

Review 4.  Moving to the Outskirts: Interplay Between Regulatory T Cells and Peripheral Tissues.

Authors:  Anna Estrada Brull; Camilla Panetti; Nicole Joller
Journal:  Front Immunol       Date:  2022-04-29       Impact factor: 8.786

5.  Schwannoma-derived growth factor must be transported into the nucleus to exert its mitogenic activity.

Authors:  H Kimura
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205

6.  Growth factors and vitamin E modify neuronal glutamate toxicity.

Authors:  D Schubert; H Kimura; P Maher
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-01       Impact factor: 11.205

7.  Transcriptional responses of cultured rat sympathetic neurons during BMP-7-induced dendritic growth.

Authors:  Michelle M Garred; Michael M Wang; Xin Guo; Christina A Harrington; Pamela J Lein
Journal:  PLoS One       Date:  2011-07-13       Impact factor: 3.240

8.  Redox Pioneer: Professor Hideo Kimura.

Authors:  David Lefer
Journal:  Antioxid Redox Signal       Date:  2018-11-01       Impact factor: 8.401

9.  RYR2, PTDSS1 and AREG genes are implicated in a Lebanese population-based study of copy number variation in autism.

Authors:  Jihane Soueid; Silva Kourtian; Nadine J Makhoul; Joelle Makoukji; Sariah Haddad; Simona S Ghanem; Firas Kobeissy; Rose-Mary Boustany
Journal:  Sci Rep       Date:  2016-01-08       Impact factor: 4.379
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.