Literature DB >> 15309166

Block of Thalamic T-Type Ca(2+) Channels by Ethosuximide Is Not the Whole Story.

Vincenzo Crunelli1, Nathalie Leresche.   

Abstract

On the basis of more than a decade of studies on the cellular effects of ethosuximide, currently, the most prudent view is that together with a block of the low threshold, T-type Ca(2)(+) current, a reduction both of the noninactivating Na(+) current, and the Ca(2)(+)-activated K(+) current in thalamic and cortical neurones contribute to the overall therapeutic action of this antiabsence medicine.

Entities:  

Year:  2002        PMID： 15309166      PMCID： PMC320973          DOI： 10.1111/j.1535-7597.2002.00024.x

Source DB:  PubMed          Journal:  Epilepsy Curr        ISSN： 1535-7511            Impact factor:   7.872


  26 in total

1.  Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels.

Authors:  D Kim; I Song; S Keum; T Lee; M J Jeong; S S Kim; M W McEnery; H S Shin
Journal:  Neuron       Date:  2001-07-19       Impact factor: 17.173

2.  Intracellular recordings in thalamic neurones during spontaneous spike and wave discharges in rats with absence epilepsy.

Authors:  D Pinault; N Leresche; S Charpier; J M Deniau; C Marescaux; M Vergnes; V Crunelli
Journal:  J Physiol       Date:  1998-06-01       Impact factor: 5.182

3.  Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction.

Authors:  D A Coulter; J R Huguenard; D A Prince
Journal:  Br J Pharmacol       Date:  1990-08       Impact factor: 8.739

4.  Voltage-dependent calcium channels as targets for convulsant and anticonvulsant alkyl-substituted thiobutyrolactones.

Authors:  R A Gross; D F Covey; J A Ferrendelli
Journal:  J Pharmacol Exp Ther       Date:  1997-02       Impact factor: 4.030

5.  Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents.

Authors:  S M Todorovic; C J Lingle
Journal:  J Neurophysiol       Date:  1998-01       Impact factor: 2.714

6.  Pharmacological characterization of calcium currents and synaptic transmission between thalamic neurons in vitro.

Authors:  F W Pfrieger; N S Veselovsky; K Gottmann; H D Lux
Journal:  J Neurosci       Date:  1992-11       Impact factor: 6.167

7.  Different action of ethosuximide on low- and high-threshold calcium currents in rat sensory neurons.

Authors:  P G Kostyuk; E A Molokanova; N F Pronchuk; A N Savchenko; A N Verkhratsky
Journal:  Neuroscience       Date:  1992-12       Impact factor: 3.590

8.  Mechanisms of oscillatory activity in guinea-pig nucleus reticularis thalami in vitro: a mammalian pacemaker.

Authors:  T Bal; D A McCormick
Journal:  J Physiol       Date:  1993-08       Impact factor: 5.182

9.  Relations between cortical and thalamic cellular events during transition from sleep patterns to paroxysmal activity.

Authors:  M Steriade; D Contreras
Journal:  J Neurosci       Date:  1995-01       Impact factor: 6.167

10.  On the action of the anti-absence drug ethosuximide in the rat and cat thalamus.

Authors:  N Leresche; H R Parri; G Erdemli; A Guyon; J P Turner; S R Williams; E Asprodini; V Crunelli
Journal:  J Neurosci       Date:  1998-07-01       Impact factor: 6.167
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  25 in total

Review 1.  Molecular targets for antiepileptic drug development.

Authors:  Brian S Meldrum; Michael A Rogawski
Journal:  Neurotherapeutics       Date:  2007-01       Impact factor: 7.620

Review 2.  Targeting BK (big potassium) channels in epilepsy.

Authors:  Prosper N'Gouemo
Journal:  Expert Opin Ther Targets       Date:  2011-09-19       Impact factor: 6.902

Review 3.  Low threshold T-type calcium channels as targets for novel epilepsy treatments.

Authors:  Kim L Powell; Stuart M Cain; Terrance P Snutch; Terence J O'Brien
Journal:  Br J Clin Pharmacol       Date:  2014-05       Impact factor: 4.335

4.  Ethosuximide reduces electrographical and behavioral correlates of alcohol withdrawal seizure in DBA/2J mice.

Authors:  Melissa A Riegle; Melissa L Masicampo; Erin H Caulder; Dwayne W Godwin
Journal:  Alcohol       Date:  2014-05-04       Impact factor: 2.405

5.  Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I(T)window.

Authors:  Fanny M Dreyfus; Anne Tscherter; Adam C Errington; John J Renger; Hee-Sup Shin; Victor N Uebele; Vincenzo Crunelli; Régis C Lambert; Nathalie Leresche
Journal:  J Neurosci       Date:  2010-01-06       Impact factor: 6.167

6.  Ethosuximide reduces ethanol withdrawal-mediated disruptions in sleep-related EEG patterns.

Authors:  Walter F Wiggins; John D Graef; Tiffany W Huitt; Dwayne W Godwin
Journal:  Alcohol Clin Exp Res       Date:  2012-10-18       Impact factor: 3.455

7.  Early treatment suppresses the development of spike-wave epilepsy in a rat model.

Authors:  Hal Blumenfeld; Joshua P Klein; Ulrich Schridde; Matthew Vestal; Timothy Rice; Davender S Khera; Chhitij Bashyal; Kathryn Giblin; Crystal Paul-Laughinghouse; Frederick Wang; Anuradha Phadke; John Mission; Ravi K Agarwal; Dario J Englot; Joshua Motelow; Hrachya Nersesyan; Stephen G Waxman; April R Levin
Journal:  Epilepsia       Date:  2007-12-06       Impact factor: 5.864

Review 8.  Potassium Channels in Epilepsy.

Authors:  Rüdiger Köhling; Jakob Wolfart
Journal:  Cold Spring Harb Perspect Med       Date:  2016-05-02       Impact factor: 6.915

9.  Flow- and voltage-dependent blocking effect of ethosuximide on the inward rectifier K⁺ (Kir2.1) channel.

Authors:  Chiung-Wei Huang; Chung-Chin Kuo
Journal:  Pflugers Arch       Date:  2014-09-16       Impact factor: 3.657

10.  Integrative properties and transfer function of cortical neurons initiating absence seizures in a rat genetic model.

Authors:  Mark S Williams; Tristan Altwegg-Boussac; Mario Chavez; Sarah Lecas; Séverine Mahon; Stéphane Charpier
Journal:  J Physiol       Date:  2016-08-08       Impact factor: 5.182
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