| Literature DB >> 1336826 |
P G Kostyuk1, E A Molokanova, N F Pronchuk, A N Savchenko, A N Verkhratsky.
Abstract
The effects of ethosuximide on calcium channels were studied on dorsal root ganglion neurons from one-day-old rats using the patch-clamp technique. Bath application of ethosuximide induced dose-dependent and reversible suppression of calcium currents without affecting their time-course. Substantial differences between the effects of ethosuximide on the low-threshold and high-threshold (T- and L-) currents were observed. Ethosuximide reduced the T-current with greater potency than the L-current (Kd for T-current is 7 microM vs 15 microM for L-current). This relative specificity of its action still remained if applied at concentrations up to 1 mM. These data support the hypothesis according to which the anti-epileptic action of ethosuximide is related to reduction of the low-threshold calcium currents in sensory neurons.Entities:
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Year: 1992 PMID： 1336826 DOI： 10.1016/0306-4522(92)90515-4
Source DB: PubMed Journal: Neuroscience ISSN： 0306-4522 Impact factor: 3.590