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Literature DB >> 15309165

Block of T -Type Ca(2+) Channels Is an Important Action of Succinimide Antiabsence Drugs.

Abstract

The role of calcium channel blockade in the antiepileptic action of ethosuximide is controversial, especially regarding the potency and efficacy of block. However, recent evidence obtained from transgenic animals and heterologous expression systems supports a major role of T-type calcium channels in both the generation of absence seizures and the action of ethosuximide in human absence epilepsy.

Entities: Chemical

Year: 2002 PMID： 15309165 PMCID： PMC320968 DOI： 10.1111/j.1535-7597.2002.00019.x

Source DB: PubMed Journal: Epilepsy Curr ISSN： 1535-7511 Impact factor: 7.872

22 in total

1. Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels.

Authors: D Kim; I Song; S Keum; T Lee; M J Jeong; S S Kim; M W McEnery; H S Shin
Journal: Neuron Date: 2001-07-19 Impact factor: 17.173

2. Low-voltage-activated calcium channel subunit expression in a genetic model of absence epilepsy in the rat.

Authors: E M Talley; G Solórzano; A Depaulis; E Perez-Reyes; D A Bayliss
Journal: Brain Res Mol Brain Res Date: 2000-01-10

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Journal: J Neurophysiol Date: 1994-10 Impact factor: 2.714

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5. Physiology and pharmacology of corticothalamic stimulation-evoked responses in rat somatosensory thalamic neurons in vitro.

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Journal: J Neurophysiol Date: 1997-05 Impact factor: 2.714

6. Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction.

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Journal: Br J Pharmacol Date: 1990-08 Impact factor: 8.739

7. Voltage-dependent calcium channels as targets for convulsant and anticonvulsant alkyl-substituted thiobutyrolactones.

Authors: R A Gross; D F Covey; J A Ferrendelli
Journal: J Pharmacol Exp Ther Date: 1997-02 Impact factor: 4.030

8. Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents.

Authors: S M Todorovic; C J Lingle
Journal: J Neurophysiol Date: 1998-01 Impact factor: 2.714

9. Multiple channel types contribute to the low-voltage-activated calcium current in hippocampal CA3 pyramidal neurons.

Authors: R B Avery; D Johnston
Journal: J Neurosci Date: 1996-09-15 Impact factor: 6.167

10. On the action of the anti-absence drug ethosuximide in the rat and cat thalamus.

Authors: N Leresche; H R Parri; G Erdemli; A Guyon; J P Turner; S R Williams; E Asprodini; V Crunelli
Journal: J Neurosci Date: 1998-07-01 Impact factor: 6.167

14 in total

1. Nerve terminal nicotinic acetylcholine receptors initiate quantal GABA release from perisomatic interneurons by activating axonal T-type (Cav3) Ca²⁺ channels and Ca²⁺ release from stores.

Authors: Ai-Hui Tang; Miranda A Karson; Daniel A Nagode; J Michael McIntosh; Victor N Uebele; John J Renger; Matthias Klugmann; Teresa A Milner; Bradley E Alger
Journal: J Neurosci Date: 2011-09-21 Impact factor: 6.167

2. Genetic variants in absence epilepsy: a contextual consideration of calcium current kinetics.

Authors: Andre Lagrange
Journal: Epilepsy Curr Date: 2006 May-Jun Impact factor: 7.500

3. Bidirectional Control of Generalized Epilepsy Networks via Rapid Real-Time Switching of Firing Mode.

Authors: Jordan M Sorokin; Thomas J Davidson; Eric Frechette; Armen M Abramian; Karl Deisseroth; John R Huguenard; Jeanne T Paz
Journal: Neuron Date: 2016-12-15 Impact factor: 17.173

4. Ethosuximide reduces electrographical and behavioral correlates of alcohol withdrawal seizure in DBA/2J mice.

Authors: Melissa A Riegle; Melissa L Masicampo; Erin H Caulder; Dwayne W Godwin
Journal: Alcohol Date: 2014-05-04 Impact factor: 2.405

Review 5. Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet.

Authors: Michael A Rogawski; Wolfgang Löscher; Jong M Rho
Journal: Cold Spring Harb Perspect Med Date: 2016-05-02 Impact factor: 6.915

Review 6. Targeting voltage-gated calcium channels in neurological and psychiatric diseases.

Authors: Gerald W Zamponi
Journal: Nat Rev Drug Discov Date: 2015-11-06 Impact factor: 84.694

7. Role of T-type Calcium Channels in Generating Hyperexcitatory Behaviors during Emergence from Sevoflurane Anesthesia in Neonatal Rats.

Authors: Feng-Yan Shen; Byung-Gun Lim; Wen Wen; Yu Zhang; Bo Cao; Yue-Guang Si; Li-Qing Ma; Meng Deng; Yang In Kim; Young-Beom Kim; Ying-Wei Wang
Journal: Neurosci Bull Date: 2020-01-17 Impact factor: 5.203

8. The Epileptic Neuron Redux.

Authors: F Edward Dudek; Michael A. Rogawski
Journal: Epilepsy Curr Date: 2002-09 Impact factor: 7.872

Review 9. The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential.

Authors: Gerald W Zamponi; Joerg Striessnig; Alexandra Koschak; Annette C Dolphin
Journal: Pharmacol Rev Date: 2015-10 Impact factor: 25.468

10. The Transcription Factor Shox2 Shapes Neuron Firing Properties and Suppresses Seizures by Regulation of Key Ion Channels in Thalamocortical Neurons.

Authors: Diankun Yu; Isabella G Febbo; Matthieu J Maroteaux; Hanyun Wang; Yingnan Song; Xiao Han; Cheng Sun; Emily E Meyer; Stuart Rowe; Yiping Chen; Carmen C Canavier; Laura A Schrader
Journal: Cereb Cortex Date: 2021-06-10 Impact factor: 5.357