| Literature DB >> 15308207 |
Patricia Wadsworth1, Alexey Khodjakov.
Abstract
Recent data have revealed that the mitotic spindle might form by centrosome-independent mechanisms, even in centrosome-containing cells. This suggests that spindle assembly might proceed by a generally conserved acentrosomal mechanism in all higher eukaryotes, regardless of the presence of centrosomes. Thus, what is the role of centrosomes in mitosis? We propose that these organelles are needed to generate radial arrays of microtubules that integrate preassembled (by centrosome-independent mechanisms) spindle components into a common spindle and orientate the spindle within malleable animal cells.Mesh：
Year: 2004 PMID： 15308207 DOI： 10.1016/j.tcb.2004.07.004
Source DB: PubMed Journal: Trends Cell Biol ISSN： 0962-8924 Impact factor: 20.808