Perspectives on the role of ultrasonic devices in thrombolysis.

Reperfusion strategies in acute myocardial infarction and thrombotic vascular occlusion are focused on rapid and complete restoration of antegrade flow in the infarct-related artery in order to maximize myocardial salvage. Due to the limitations of fibrinolytic agents in restoration of vascular flow, ultrasonic clot dissolution alone and concomitantly with fibrinolytic, anti-thrombotic and echocardiographic contrast agents has been intensively studied during the last 2 decades. Ultrasound thrombolysis has been tested in-vitro and in-vivo as well as in patients with acute thrombotic occlusions. We review currently available techniques and methods of ultrasonic thrombolysis and present recent clinical and experimental data. The future role of ultrasonic thrombolysis and the strategy of "power thrombectomy" for treatment of acute coronary syndromes is also discussed.