Literature DB >> 15305321

Cyclooxygenase inhibitory flavonoids from the stem bark of Semecarpus anacardium Linn.

C Selvam1, Sanjay M Jachak, K K Bhutani.   

Abstract

The ethyl acetate extract of stem bark of Semecarpus anacardium showing in vivo anti-in fl ammatory activity in carrageenan induced rat paw edema assay was investigated in order to identify its active compounds. Chemical investigation of the ethyl acetate extract of S.anacardium afforded 3,4,2',4'-tetrahydroxychalcone (butein) and 7,3',4'-trihydroxy fl avone. Evaluation of COX-1 inhibitory activity of 3,4,2',4'-tetrahydroxychalcone and 7,3',4'-trihydroxy fl avone provided the IC(50) values of 28.4 and 36.7 micro M respectively. Further investigation of these compounds for COX-2 inhibitory activity revealed moderate potency towards this enzyme.

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Year:  2004        PMID： 15305321     DOI： 10.1002/ptr.1492

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  8 in total

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