Literature DB >> 15302197

Effectiveness of leucoreduction for removal of infectivity of transmissible spongiform encephalopathies from blood.

Luisa Gregori1, Nancy McCombie, Douglas Palmer, Paul Birch, Samuel O Sowemimo-Coker, Antonio Giulivi, Robert G Rohwer.   

Abstract

In 1999, the UK implemented universal leucoreduction as a precaution against transmission of variant Creutzfeldt-Jakob disease by transfusion of domestic blood or red blood cells. We aimed to assess how effectively leucoreduction reduced infectivity of transmissible spongiform encephalopathies (TSEs) in blood. 450 mL of whole blood collected and pooled from scrapie-infected hamsters was leucoreduced with a commercial filter. Blood cell concentrations were quantified, and infectivity titres measured. Blood cell recovery and white blood cell removal complied with American Association of Blood Banks standards. Leucofiltration removed 42% (SD 12) of the total TSE infectivity in endogenously infected blood. Leucoreduction is necessary for the removal of white-cell-associated TSE infectivity from blood; however, it is not, by itself, sufficient to remove all blood-borne TSE infectivity.

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Year:  2004        PMID： 15302197     DOI： 10.1016/S0140-6736(04)16812-8

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  39 in total

Review 1.  Leucoreduction of blood components: an effective way to increase blood safety?

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2.  Appropriateness and safety of blood transfusion.

Authors:  Brian McClelland; Marcela Contreras
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3.  Is there the potential for an epidemic of variant Creutzfeldt-Jakob disease via blood transfusion in the UK?

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9.  Excretion of transmissible spongiform encephalopathy infectivity in urine.

Authors:  Luisa Gregori; Gabor G Kovacs; Irina Alexeeva; Herbert Budka; Robert G Rohwer
Journal:  Emerg Infect Dis       Date:  2008-09       Impact factor: 6.883

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