Literature DB >> 15296098

A novel antifungal pyrrole derivative from Datura metel leaves.

R Dabur1, M Ali, H Singh, J Gupta, G L Sharma.   

Abstract

Phytochemical investigation of the leaves of Datura metel Linn. led to the isolation of a new pyrrole derivative 1 which was characterised as 2beta-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1'-methylethyl pentanoate on the basis of spectral data analyses and chemical reactions. Compound 1 was endowed with antifungal activity and its MIC was found to be 87.5 microg/ml. Two proteins having molecular weights of 42 and 58 kD of Aspergillus fumigatus are potential targets for compound 1.

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Year:  2004        PMID： 15296098

Source DB:  PubMed          Journal:  Pharmazie        ISSN： 0031-7144            Impact factor:   1.267


  7 in total

1.  Antimicrobial activity of some Indian medicinal plants.

Authors:  Rajesh Dabur; Amita Gupta; T K Mandal; Desh Deepak Singh; Vivek Bajpai; A M Gurav; G S Lavekar
Journal:  Afr J Tradit Complement Altern Med       Date:  2007-02-16

2.  Efficacy of 2-(3,4-dimethyl-2,5-dihydro-1h-pyrrole-2-yl)-1-methylethyl pentanoate in a murine model of invasive aspergillosis.

Authors:  Rajesh Dabur; S K Diwedi; V Yadav; V Mishra; Rambir Singh; H Singh; G L Sharma
Journal:  Antimicrob Agents Chemother       Date:  2005-10       Impact factor: 5.191

3.  Characterization of the Escherichia coli Antifungal Protein PPEBL21.

Authors:  V Yadav; R Mandhan; M Kumar; J Gupta; G L Sharma
Journal:  Int J Microbiol       Date:  2010-05-17

4.  Potent In Vitro α-Glucosidase and β-Secretase Inhibition of Amyrin-Type Triterpenoid Isolated from Datura metel Linnaeus (Angel's Trumpet) Fruits.

Authors:  Saud Bawazeer; Abdur Rauf; Sami Bawazeer
Journal:  Biomed Res Int       Date:  2020-08-25       Impact factor: 3.411

5.  Antifungal Treatments Delineate a Correlation between Cathepsins and Cytokines in Murine Model of Invasive Aspergillosis.

Authors:  Ashwani Mittal; Anjum Gahlaut; G L Sharma; R Dabur
Journal:  Indian J Pharm Sci       Date:  2013-11       Impact factor: 0.975

6.  Synthesis of novel pyrroles and fused pyrroles as antifungal and antibacterial agents.

Authors:  Rania Helmy Abd El-Hameed; Amira Ibrahim Sayed; Shima Mahmoud Ali; Mohamed A Mosa; Zainab M Khoder; Samar Said Fatahala
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

7.  In Vitro Antibacterial and Antifungal Potential of Amyrin-Type Triterpenoid Isolated from Datura metel Linnaeus.

Authors:  Sami Bawazeer; Abdur Rauf
Journal:  Biomed Res Int       Date:  2021-09-18       Impact factor: 3.411
  7 in total

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