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Literature DB >> 15295589

Pathways towards and away from Alzheimer's disease.

Abstract

Slowly but surely, Alzheimer's disease (AD) patients lose their memory and their cognitive abilities, and even their personalities may change dramatically. These changes are due to the progressive dysfunction and death of nerve cells that are responsible for the storage and processing of information. Although drugs can temporarily improve memory, at present there are no treatments that can stop or reverse the inexorable neurodegenerative process. But rapid progress towards understanding the cellular and molecular alterations that are responsible for the neuron's demise may soon help in developing effective preventative and therapeutic strategies.

Entities: Disease Species

Mesh：

Substances：

Year: 2004 PMID： 15295589 PMCID： PMC3091392 DOI： 10.1038/nature02621

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

99 in total

Review 1. Synaptic frailty and clathrin-mediated synaptic vesicle trafficking in Alzheimer's disease.

Authors: Pamela J Yao
Journal: Trends Neurosci Date: 2004-01 Impact factor: 13.837

Review 2. Epidemiology of neurodegeneration.

Authors: Richard Mayeux
Journal: Annu Rev Neurosci Date: 2003-01-24 Impact factor: 12.449

3. Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection.

Authors: Ashley I Bush; Colin L Masters; Rudolph E Tanzi
Journal: Proc Natl Acad Sci U S A Date: 2003-09-23 Impact factor: 11.205

Review 4. Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease.

Authors: Anne Eckert; Uta Keil; Celio A Marques; Astrid Bonert; Claudia Frey; Katrin Schüssel; Walter E Müller
Journal: Biochem Pharmacol Date: 2003-10-15 Impact factor: 5.858

Review 5. Human beta-secretase (BACE) and BACE inhibitors.

Authors: Varghese John; James P Beck; Michael J Bienkowski; Sukanto Sinha; Robert L Heinrikson
Journal: J Med Chem Date: 2003-10-23 Impact factor: 7.446

6. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study.

Authors: Peter P Zandi; James C Anthony; Ara S Khachaturian; Stephanie V Stone; Deborah Gustafson; JoAnn T Tschanz; Maria C Norton; Kathleen A Welsh-Bohmer; John C S Breitner
Journal: Arch Neurol Date: 2004-01

7. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial.

Authors: Craig W Ritchie; Ashley I Bush; Andrew Mackinnon; Steve Macfarlane; Maree Mastwyk; Lachlan MacGregor; Lyn Kiers; Robert Cherny; Qiao-Xin Li; Amanda Tammer; Darryl Carrington; Christine Mavros; Irene Volitakis; Michel Xilinas; David Ames; Stephen Davis; Konrad Beyreuther; Rudolph E Tanzi; Colin L Masters
Journal: Arch Neurol Date: 2003-12

Review 8. Gene-diet interactions in brain aging and neurodegenerative disorders.

Authors: Mark P Mattson
Journal: Ann Intern Med Date: 2003-09-02 Impact factor: 25.391

9. Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses.

Authors: E-M Mandelkow; K Stamer; R Vogel; E Thies; E Mandelkow
Journal: Neurobiol Aging Date: 2003-12 Impact factor: 4.673

10. Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity.

Authors: Sungmin Song; So-Young Kim; Yeon-Mi Hong; Dong-Gyu Jo; Joo-Yong Lee; Sang Mi Shim; Chul-Woong Chung; Soo Jung Seo; Yung Joon Yoo; Jae-Young Koh; Min Chul Lee; Allan J Yates; Hidenori Ichijo; Yong-Keun Jung
Journal: Mol Cell Date: 2003-09 Impact factor: 17.970

839 in total

Review 1. Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis.

Authors: Norman J Haughey; Veera V R Bandaru; Mihyun Bae; Mark P Mattson
Journal: Biochim Biophys Acta Date: 2010-05-07

2. Inhibitors of catalase-amyloid interactions protect cells from beta-amyloid-induced oxidative stress and toxicity.

Authors: Lila K Habib; Michelle T C Lee; Jerry Yang
Journal: J Biol Chem Date: 2010-10-05 Impact factor: 5.157

3. Endocannabinoids prevent β-amyloid-mediated lysosomal destabilization in cultured neurons.

Authors: Janis Noonan; Riffat Tanveer; Allan Klompas; Aoife Gowran; Joanne McKiernan; Veronica A Campbell
Journal: J Biol Chem Date: 2010-10-05 Impact factor: 5.157

4. Single-cell screening of cytosolic [Ca(2+)] reveals cell-selective action by the Alzheimer's Aβ peptide ion channel.

Authors: Hopi Lin; Nelson J Arispe
Journal: Cell Stress Chaperones Date: 2014-11-01 Impact factor: 3.667

Review 5. The emerging field of epigenetics in neurodegeneration and neuroprotection.

Authors: Jee-Yeon Hwang; Kelly A Aromolaran; R Suzanne Zukin
Journal: Nat Rev Neurosci Date: 2017-05-18 Impact factor: 34.870

6. TOMM40 in Cerebral Amyloid Angiopathy Related Intracerebral Hemorrhage: Comparative Genetic Analysis with Alzheimer's Disease.

Authors: Valerie Valant; Brendan T Keenan; Christopher D Anderson; Joshua M Shulman; William J Devan; Alison M Ayres; Kristin Schwab; Joshua N Goldstein; Anand Viswanathan; Steven M Greenberg; David A Bennett; Philip L De Jager; Jonathan Rosand; Alessandro Biffi
Journal: Transl Stroke Res Date: 2012-04-12 Impact factor: 6.829

7. Permeability transition pore-mediated mitochondrial superoxide flashes mediate an early inhibitory effect of amyloid beta1-42 on neural progenitor cell proliferation.

Authors: Yan Hou; Paritosh Ghosh; Ruiqian Wan; Xin Ouyang; Heping Cheng; Mark P Mattson; Aiwu Cheng
Journal: Neurobiol Aging Date: 2013-11-13 Impact factor: 4.673

Review 8. Glutamate and neurotrophic factors in neuronal plasticity and disease.

Authors: Mark P Mattson
Journal: Ann N Y Acad Sci Date: 2008-11 Impact factor: 5.691

9. Oral delivery of bioencapsulated proteins across blood-brain and blood-retinal barriers.

Authors: Neha Kohli; Donevan R Westerveld; Alexandra C Ayache; Amrisha Verma; Pollob Shil; Tuhina Prasad; Ping Zhu; Sic L Chan; Qiuhong Li; Henry Daniell
Journal: Mol Ther Date: 2013-12-06 Impact factor: 11.454

10. Constitutively active Akt inhibits trafficking of amyloid precursor protein and amyloid precursor protein metabolites through feedback inhibition of phosphoinositide 3-kinase.

Authors: Diana W Shineman; Aleksandra S Dain; Minkyu L Kim; Virginia M-Y Lee
Journal: Biochemistry Date: 2009-05-05 Impact factor: 3.162