| Literature DB >> 15289021 |
Florian Länger1, Juliane Stickel, Mathewos Tessema, Hans Kreipe, Ulrich Lehmann.
Abstract
The mRNA expression level of the gene delta-like (Dlk), coding for a signal transducer related to the Delta-Notch family, was measured using real-time PCR methodology in a large series of control biopsies (n = 61) and bone marrow trephines from patients with myelodysplastic syndrome (MDS) (n = 93) and related myeloid disorders (AML, n = 16 and chronic myeloproliferative disease (CMPD), n = 38). It turned out that dlk is strongly overexpressed in a subset of MDS (16%) cases, however with higher frequency in blast rich MDS cases. Therefore, the quantitative detection of dlk mRNA can support the morphological diagnosis of MDS in selected cases.Entities:
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Year: 2004 PMID： 15289021 DOI： 10.1016/j.leukres.2004.01.020
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156