OBJECTIVE:Placebo effects in treatment of three anxiety disorders were compared. METHOD: Treatment response and patients' treatment expectancy were examined by using data from 70 patients with obsessive-compulsive disorder, social phobia, or panic disorder who receivedplacebo in three randomized, controlled trials comparing cognitive behavior therapy, medication, and their combination to placebo. RESULTS:Patients with obsessive-compulsive disorder were less likely to respond to placebo than patients with generalized social phobia or panic disorder. Differential expectancy did not account for these findings. CONCLUSIONS: Further examination of the placebo effect across the anxiety disorders may elucidate maintenance mechanisms of these disorders and have implications for development of more effective treatments.
RCT Entities:
OBJECTIVE: Placebo effects in treatment of three anxiety disorders were compared. METHOD: Treatment response and patients' treatment expectancy were examined by using data from 70 patients with obsessive-compulsive disorder, social phobia, or panic disorder who received placebo in three randomized, controlled trials comparing cognitive behavior therapy, medication, and their combination to placebo. RESULTS:Patients with obsessive-compulsive disorder were less likely to respond to placebo than patients with generalized social phobia or panic disorder. Differential expectancy did not account for these findings. CONCLUSIONS: Further examination of the placebo effect across the anxiety disorders may elucidate maintenance mechanisms of these disorders and have implications for development of more effective treatments.
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Authors: Johanna Breilmann; Francesca Girlanda; Giuseppe Guaiana; Corrado Barbui; Andrea Cipriani; Mariasole Castellazzi; Irene Bighelli; Simon Jc Davies; Toshi A Furukawa; Markus Koesters Journal: Cochrane Database Syst Rev Date: 2019-03-28