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Literature DB >> 15280028

The gun4 gene is essential for cyanobacterial porphyrin metabolism.

Annegret Wilde¹, Sandra Mikolajczyk, Ali Alawady, Heiko Lokstein, Bernhard Grimm.

Abstract

Ycf53 is a hypothetical chloroplast open reading frame with similarity to the Arabidopsis nuclear gene GUN4. In plants, GUN4 is involved in tetrapyrrole biosynthesis. We demonstrate that one of the two Synechocystis sp. PCC 6803 ycf53 genes with similarity to GUN4 functions in chlorophyll (Chl) biosynthesis as well: cyanobacterial gun4 mutant cells exhibit lower Chl contents, accumulate protoporphyrin IX and show less activity not only of Mg chelatase but also of Fe chelatase. The possible role of Gun4 for the Mg as well as Fe porphyrin biosynthesis branches in Synechocystis sp. PCC 6803 is discussed.

Entities: Chemical Gene Species

Mesh：

Substances：
DNA Primers
Porphyrins

Year: 2004 PMID： 15280028 DOI： 10.1016/j.febslet.2004.06.063

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

19 in total

1. Thioredoxin redox regulates ATPase activity of magnesium chelatase CHLI subunit and modulates redox-mediated signaling in tetrapyrrole biosynthesis and homeostasis of reactive oxygen species in pea plants.

Authors: Tao Luo; Tingting Fan; Yinan Liu; Maxi Rothbart; Jing Yu; Shuaixiang Zhou; Bernhard Grimm; Meizhong Luo
Journal: Plant Physiol Date: 2012-03-27 Impact factor: 8.340

2. Importance of the cyanobacterial Gun4 protein for chlorophyll metabolism and assembly of photosynthetic complexes.

Authors: Roman Sobotka; Ulf Dühring; Josef Komenda; Enrico Peter; Zdenko Gardian; Martin Tichy; Bernhard Grimm; Annegret Wilde
Journal: J Biol Chem Date: 2008-07-14 Impact factor: 5.157

3. Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity.

Authors: Gurmeet Kaur; A Maxwell Burroughs; Lakshminarayan M Iyer; L Aravind
Journal: Elife Date: 2020-02-26 Impact factor: 8.140

4. GUN4-porphyrin complexes bind the ChlH/GUN5 subunit of Mg-Chelatase and promote chlorophyll biosynthesis in Arabidopsis.

Authors: Neil D Adhikari; John E Froehlich; Deserah D Strand; Stephanie M Buck; David M Kramer; Robert M Larkin
Journal: Plant Cell Date: 2011-04-05 Impact factor: 11.277

The gun4 gene is essential for cyanobacterial porphyrin metabolism.

1. Thioredoxin redox regulates ATPase activity of magnesium chelatase CHLI subunit and modulates redox-mediated signaling in tetrapyrrole biosynthesis and homeostasis of reactive oxygen species in pea plants.

2. Importance of the cyanobacterial Gun4 protein for chlorophyll metabolism and assembly of photosynthetic complexes.

3. Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity.

4. GUN4-porphyrin complexes bind the ChlH/GUN5 subunit of Mg-Chelatase and promote chlorophyll biosynthesis in Arabidopsis.

Review 5. Recent advances in chlorophyll biosynthesis and breakdown in higher plants.

6. HEMA RNAi silencing reveals a control mechanism of ALA biosynthesis on Mg chelatase and Fe chelatase.

Review 7. Recent overview of the Mg branch of the tetrapyrrole biosynthesis leading to chlorophylls.

8. Phosphorylation of GENOMES UNCOUPLED 4 Alters Stimulation of Mg Chelatase Activity in Angiosperms.

9. The maize Oil yellow1 (Oy1) gene encodes the I subunit of magnesium chelatase.

10. Porphyrins promote the association of GENOMES UNCOUPLED 4 and a Mg-chelatase subunit with chloroplast membranes.