| Literature DB >> 15280000 |
Luis A Loyola1, Jorge Bórquez, Glauco Morales, Aurelio San-Martín, Jose Darias, Ninoska Flores, Alberto Giménez.
Abstract
Two mulinane-type diterpenoids were isolated from Azorella compacta; namely 20-hydroxymulin-11,13-dienyl acetate and 13,14-dihydroxymulin-11-en-20-oic acid. The structures were elucidated by analysis of their spectroscopic data. These compounds, as well as three previously isolated diterpenes, were evaluated as potential in vivo growth inhibitors of Plasmodium berghei NK 65 on infected mice at an intraperitoneal dose of 10 mg/kg/day. Sixty percent and forty-two percent growth inhibition were obtained with 17-acetoxymulin-11,13-dien-20-oic acid and 13, 14-dihydroxymulin-11-en-20-oic acid, respectively.Entities:
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Year: 2004 PMID： 15280000 DOI： 10.1016/j.phytochem.2004.06.011
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072