Literature DB >> 15279789

Chk1 in the DNA damage response: conserved roles from yeasts to mammals.

Yinhuai Chen1, Yolanda Sanchez.   

Abstract

Chk1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. Studies to date have revealed striking similarities among Chk1 pathways of different organisms. In this review we discuss what is known about Chk1 activation and what downstream factors are regulated by Chk1 to counter replication blocks and DNA damage induced by UV, IR, and other genotoxic agents. Where applicable, we also compare the role of Chk1 with that of the Chk2 protein kinase in the checkpoint responses.

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Year:  2004        PMID： 15279789     DOI： 10.1016/j.dnarep.2004.03.003

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  68 in total

1.  MDDD, a 4,9-diazapyrenium derivative, is selectively toxic to glioma cells by inducing growth arrest at G0/G1 independently of p53.

Authors:  De-Hua Yu; James Macdonald; Steve Josephs; Qi Liu; Vivian Nguy; Yitzhak Tor; Flossie Wong-Staal; Qi-Xiang Li
Journal:  Invest New Drugs       Date:  2006-11       Impact factor: 3.850

Review 2.  DNA damage response.

Authors:  Giuseppina Giglia-Mari; Angelika Zotter; Wim Vermeulen
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-01-01       Impact factor: 10.005

Review 3.  Hypersensitivity phenotypes associated with genetic and synthetic inhibitor-induced base excision repair deficiency.

Authors:  Julie K Horton; Samuel H Wilson
Journal:  DNA Repair (Amst)       Date:  2006-11-20

Review 4.  In my end is my beginning: control of end resection and DSBR pathway 'choice' by cyclin-dependent kinases.

Authors:  Ralph Scully; Anyong Xie
Journal:  Oncogene       Date:  2005-04-18       Impact factor: 9.867

Review 5.  Repair of topoisomerase I-mediated DNA damage.

Authors:  Yves Pommier; Juana M Barcelo; V Ashutosh Rao; Olivier Sordet; Andrew G Jobson; Laurent Thibaut; Ze-Hong Miao; Jennifer A Seiler; Hongliang Zhang; Christophe Marchand; Keli Agama; John L Nitiss; Christophe Redon
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  2006

6.  Analyzing the ATR-mediated checkpoint using Xenopus egg extracts.

Authors:  Patrick J Lupardus; Christopher Van; Karlene A Cimprich
Journal:  Methods       Date:  2007-02       Impact factor: 3.608

7.  Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus.

Authors:  Patrick J Lupardus; Karlene A Cimprich
Journal:  Mol Biol Cell       Date:  2006-01-25       Impact factor: 4.138

8.  The histone chaperone facilitates chromatin transcription (FACT) protein maintains normal replication fork rates.

Authors:  Takuya Abe; Kazuto Sugimura; Yoshifumi Hosono; Yasunari Takami; Motomu Akita; Akari Yoshimura; Shusuke Tada; Tatsuo Nakayama; Hiromu Murofushi; Katsuzumi Okumura; Shunichi Takeda; Masami Horikoshi; Masayuki Seki; Takemi Enomoto
Journal:  J Biol Chem       Date:  2011-07-07       Impact factor: 5.157

9.  Arabidopsis WEE1 kinase controls cell cycle arrest in response to activation of the DNA integrity checkpoint.

Authors:  Kristof De Schutter; Jérôme Joubès; Toon Cools; Aurine Verkest; Florence Corellou; Elena Babiychuk; Els Van Der Schueren; Tom Beeckman; Sergeï Kushnir; Dirk Inzé; Lieven De Veylder
Journal:  Plant Cell       Date:  2007-01-05       Impact factor: 11.277

10.  The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1.

Authors:  Sinny Delacroix; Jill M Wagner; Masahiko Kobayashi; Ken-ichi Yamamoto; Larry M Karnitz
Journal:  Genes Dev       Date:  2007-06-15       Impact factor: 11.361
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