Literature DB >> 15279594

Structural approach for COX-2 inhibition.

C Michaux1, C Charlier.   

Abstract

The design of selective COX-2 inhibitors is a new approach to obtain potent, anti-inflammatory drugs but with less side effects. Several families of such inhibitors were reported in literature. In this review, the drug design processes used to understand their binding mode and the origin of selectivity of these compounds are described.

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Year:  2004        PMID： 15279594     DOI： 10.2174/1389557043403756

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  11 in total

1.  Ortho-carbaborane derivatives of indomethacin as cyclooxygenase (COX)-2 selective inhibitors.

Authors:  Matthias Scholz; Anna L Blobaum; Lawrence J Marnett; Evamarie Hey-Hawkins
Journal:  Bioorg Med Chem       Date:  2012-06-05       Impact factor: 3.641

2.  nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2.

Authors:  Wilma Neumann; Shu Xu; Menyhárt B Sárosi; Matthias S Scholz; Brenda C Crews; Kebreab Ghebreselasie; Surajit Banerjee; Lawrence J Marnett; Evamarie Hey-Hawkins
Journal:  ChemMedChem       Date:  2015-06-18       Impact factor: 3.466

3.  Binding of indomethacin methyl ester to cyclooxygenase-2. A computational study.

Authors:  Menyhárt-Botond Sárosi
Journal:  J Mol Model       Date:  2018-06-05       Impact factor: 1.810

4.  1-(4-Methoxy-phen-yl)-3-phenyl-1H-pyrazol-5-amine.

Authors:  Isuru R Kumarasinghe; Victor J Hruby; Gary S Nichol
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-04-30

5.  Nitrogen-Doped Graphene Quantum Dot-Combined Sodium 10-Amino-2-methoxyundecanoate: Studies of Proinflammatory Gene Expression and Live Cell Imaging.

Authors:  Rai Sameer Kumar; Ganeshan Shakambari; Balasubramaniem Ashokkumar; D James Nelson; S Abraham John; Perumal Varalakshmi
Journal:  ACS Omega       Date:  2018-09-26

6.  Synthesis, anti-inflammatory, cytotoxic, and COX-1/2 inhibitory activities of cyclic imides bearing 3-benzenesulfonamide, oxime, and β-phenylalanine scaffolds: a molecular docking study.

Authors:  Alaa A-M Abdel-Aziz; Adel S El-Azab; Nawaf A AlSaif; Mohammed M Alanazi; Manal A El-Gendy; Ahmad J Obaidullah; Hamad M Alkahtani; Abdulrahman A Almehizia; Ibrahim A Al-Suwaidan
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051

7.  Design, synthesis and biological evaluation of novel 1,3-diarylpyrazoles as cyclooxygenase inhibitors, antiplatelet and anticancer agents.

Authors:  Nazan Inceler; Yesim Ozkan; Nilufer Nermin Turan; Deniz Cansen Kahraman; Rengul Cetin-Atalay; Sultan Nacak Baytas
Journal:  Medchemcomm       Date:  2018-04-06       Impact factor: 3.597

8.  Molecular docking analysis of known flavonoids as duel COX-2 inhibitors in the context of cancer.

Authors:  Raju Dash; Mir Muhammad Nasir Uddin; S M Zahid Hosen; Zahed Bin Rahim; Abu Mansur Dinar; Mohammad Shah Hafez Kabir; Ramiz Ahmed Sultan; Ashekul Islam; Md Kamrul Hossain
Journal:  Bioinformation       Date:  2015-12-31

9.  Microwave Assisted Synthesis, Pharmacological Activities, and Molecular Docking Studies of Ethyl 2-[2-Substituted-4-(Thiophenyl) Thiazolyl] Acetates.

Authors:  Mahesh Veerabhadra Attimarad; Mohammed Abdou Khedr; Bandar Essa Aldhubiab
Journal:  Iran J Pharm Res       Date:  2017       Impact factor: 1.696

10.  Synergy of Physico-chemical and Biological Experiments for Developing a Cyclooxygenase-2 Inhibitor.

Authors:  Palwinder Singh; Jagroop Kaur; Harpreet Kaur; Anudeep Kaur; Rajbir Bhatti
Journal:  Sci Rep       Date:  2018-07-03       Impact factor: 4.379
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