Literature DB >> 15278604

Protective effects of prostaglandin I2 analogues on CPK release in rat's heart-lung preparation.

S Kashimoto1, T Nakamura, T Oguchi, M Kume, T Kumazawa.   

Abstract

The effects of prostaglandin I(2) analogues (PGI(2)-a: op-41483 and op-2507) on oxygen toxicity during hyperoxic perfusion were evaluated in an experiment on isolated rat heart lung preparation, with the release of creatine phosphokinase (CPK) in the perfusate blood. There were no significant differences in heart rate and right atrial pressure between PGI(2)-a treated and untreated hearts. The CPK release from the heart with oxygen was significantly higher than that of the air ( P < 0.001). However, the CPK release from the PGI(2)-a treated hearts was significantly less than that from the untreated hearts ( P < 0.05). These results indicate that PGI(2)-a may prevent cell damage which was induced by hyperoxia.

Entities:  

Year:  1991        PMID： 15278604     DOI： 10.1007/s0054010050359

Source DB:  PubMed          Journal:  J Anesth        ISSN： 0913-8668            Impact factor:   2.078


  17 in total

1.  Prostacyclin: a potentially valuable agent for preserving myocardial tissue in acute myocardial ischemia.

Authors:  A M Lefer; M L Ogletree; J B Smith; M J Silver; K C Nicolaou; W E Barnette; G P Gasic
Journal:  Science       Date:  1978-04-07       Impact factor: 47.728

2.  Effect of a prostacyclin analog OP-2507 on acute ischemic cerebral edema in cats.

Authors:  T Terawaki; T Takakuwa; S Iguchi; K Wakitani; H Kira; T Okegawa; A Kawasaki; Y Masuda
Journal:  Eur J Pharmacol       Date:  1988-07-26       Impact factor: 4.432

3.  Prevention of blockage of partially obstructed coronary arteries with prostacyclin correlates with inhibition of platelet aggregation.

Authors:  J W Aiken; R R Gorman; R J Shebuski
Journal:  Prostaglandins       Date:  1979-04

4.  Studies on antiplatelet effects of OP-41483, a prostaglandin I2 analog, in experimental animals. II. Mechanism of its antiplatelet effect.

Authors:  B Fujitani; K Wakitani
Journal:  Jpn J Pharmacol       Date:  1990-05

5.  Beneficial effects of a new carbacyclin derivative, ZK 36 374, in acute myocardial ischemia.

Authors:  K Schrör; R Ohlendorf; H Darius
Journal:  J Pharmacol Exp Ther       Date:  1981-10       Impact factor: 4.030

6.  Beneficial actions of prostacyclin in traumatic shock.

Authors:  A M Lefer; S L Sollott; M J Galvin
Journal:  Prostaglandins       Date:  1979-05

7.  PGI2 prevents ischemia-induced alterations in cardiac catecholamines without influencing nerve-stimulation-induced catecholamine release in nonischemic conditions.

Authors:  K Schrör; H Darius; K Addicks; R Köster; E F Smith
Journal:  J Cardiovasc Pharmacol       Date:  1982 Sep-Oct       Impact factor: 3.105

8.  Prostaglandin I2 and indomethacin prevent impairment of post-ischemic brain reperfusion in the dog.

Authors:  J M Hallenbeck; T W Furlow
Journal:  Stroke       Date:  1979 Nov-Dec       Impact factor: 7.914

9.  Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachindonic acid.

Authors:  G J Dusting; S Moncada; J R Vane
Journal:  Prostaglandins       Date:  1977-01

10.  Protective effects of superoxide dismutase against oxygen toxicity in rat's heart lung preparation.

Authors:  S Kashimoto; T Kumazawa
Journal:  Jpn Circ J       Date:  1987-09
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  1 in total

1.  Effects of prostacyclin analogue, OP-2507, on function and metabolism in the ischemic working rat heart.

Authors:  T Oguchi; S Kashimoto; T Nakamura; T Kumazawa
Journal:  J Anesth       Date:  1992-10       Impact factor: 2.078
  1 in total

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