A Lavy1, Y Neeman, B Fuhrman. 1. The Lipid Research Laboratory, Technion Faculty of Medicine The Rappaport Family Institute for Research in the Medical Sciences, and Gastroenterology Bnai Zion Medical Center, Haifa, Israel. lavya@netvision.net.il
Abstract
BACKGROUND: Lipid peroxidation is an important process in the development of atherosclerosis. Thus agents with antioxidant properties may play an important role in the inhibition of atherosclerosis. OBJECTIVES: In this study we aimed to show that the lipid extract of the bacteria Deinococcus radiophilus (leDR) has antioxidant properties against LDL oxidation. RESULTS: This antioxidant effect was shown in both transition metal ion and free radical generating systems. We also showed that leDR can protect LDL from UV light-induced oxidative damage. The antioxidative capacity of leDR is partly due to copper ion chelation. CONCLUSION: We conclude that some specific bacteria constituent has the ability to inhibit LDL oxidation and, thus, to attenuate atherogenesis.
BACKGROUND:Lipid peroxidation is an important process in the development of atherosclerosis. Thus agents with antioxidant properties may play an important role in the inhibition of atherosclerosis. OBJECTIVES: In this study we aimed to show that the lipid extract of the bacteria Deinococcus radiophilus (leDR) has antioxidant properties against LDL oxidation. RESULTS: This antioxidant effect was shown in both transition metal ion and free radical generating systems. We also showed that leDR can protect LDL from UV light-induced oxidative damage. The antioxidative capacity of leDR is partly due to copper ion chelation. CONCLUSION: We conclude that some specific bacteria constituent has the ability to inhibit LDL oxidation and, thus, to attenuate atherogenesis.