Literature DB >> 15275047

LD1 amplifications in Leishmania.

M Segovia1, G Ortiz.   

Abstract

The genome of Leishmania is quite plastic. Chromosomal rearrangements and DNA amplifications are common events in all the species of the genus. Gene amplification occurs both as a mechanism of drug resistance and in the absence of drug pressure. The best known spontaneous amplification in Leishmania is the so-called LD1 family of amplicons. In the past few years there have been great advances in our knowledge of LD1 elements; here, Manuel Segovia and Ginés Ortiz review all the available data.

Entities:  

Year:  1997        PMID： 15275047     DOI： 10.1016/s0169-4758(97)01111-3

Source DB:  PubMed          Journal:  Parasitol Today        ISSN： 0169-4758


  10 in total

1.  Effect of large targeted deletions on the mitotic stability of an extra chromosome mediating drug resistance in Leishmania.

Authors:  P Dubessay; C Ravel; P Bastien; M F Lignon; B Ullman; M Pagès; C Blaineau
Journal:  Nucleic Acids Res       Date:  2001-08-01       Impact factor: 16.971

2.  Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae.

Authors:  C Kündig; A Haimeur; D Légaré; B Papadopoulou; M Ouellette
Journal:  EMBO J       Date:  1999-05-04       Impact factor: 11.598

3.  Linear amplicons as precursors of amplified circles in methotrexate-resistant Leishmania tarentolae.

Authors:  K Grondin; C Kündig; G Roy; M Ouellette
Journal:  Nucleic Acids Res       Date:  1998-07-15       Impact factor: 16.971

4.  Global genome diversity of the Leishmania donovani complex.

Authors:  Susanne U Franssen; Caroline Durrant; Olivia Stark; Bettina Moser; Tim Downing; Hideo Imamura; Jean-Claude Dujardin; Mandy J Sanders; Isabel Mauricio; Michael A Miles; Lionel F Schnur; Charles L Jaffe; Abdelmajeed Nasereddin; Henk Schallig; Matthew Yeo; Tapan Bhattacharyya; Mohammad Z Alam; Matthew Berriman; Thierry Wirth; Gabriele Schönian; James A Cotton
Journal:  Elife       Date:  2020-03-25       Impact factor: 8.140

5.  Telomerase in kinetoplastid parasitic protozoa.

Authors:  M I Cano; J M Dungan; N Agabian; E H Blackburn
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

6.  Reduced infectivity of a Leishmania donovani biopterin transporter genetic mutant and its use as an attenuated strain for vaccination.

Authors:  Barbara Papadopoulou; Gaétan Roy; Marie Breton; Christoph Kündig; Carole Dumas; Isabelle Fillion; Ajay K Singh; Martin Olivier; Marc Ouellette
Journal:  Infect Immun       Date:  2002-01       Impact factor: 3.441

7.  The genome of Leishmania panamensis: insights into genomics of the L. (Viannia) subgenus.

Authors:  Alejandro Llanes; Carlos Mario Restrepo; Gina Del Vecchio; Franklin José Anguizola; Ricardo Lleonart
Journal:  Sci Rep       Date:  2015-02-24       Impact factor: 4.379

8.  The SIDER2 elements, interspersed repeated sequences that populate the Leishmania genomes, constitute subfamilies showing chromosomal proximity relationship.

Authors:  Jose M Requena; Cristina Folgueira; Manuel C López; M Carmen Thomas
Journal:  BMC Genomics       Date:  2008-06-02       Impact factor: 3.969

9.  Leishmania naiffi and Leishmania guyanensis reference genomes highlight genome structure and gene evolution in the Viannia subgenus.

Authors:  Simone Coughlan; Ali Shirley Taylor; Eoghan Feane; Mandy Sanders; Gabriele Schonian; James A Cotton; Tim Downing
Journal:  R Soc Open Sci       Date:  2018-04-25       Impact factor: 2.963

10.  Environmental Conditions May Shape the Patterns of Genomic Variations in Leishmania panamensis.

Authors:  Carlos M Restrepo; Alejandro Llanes; Eymi M Cedeño; Jim H Chang; Jennifer Álvarez; Margarita Ríos; Homero Penagos; José A Suárez; Ricardo Lleonart
Journal:  Genes (Basel)       Date:  2019-10-24       Impact factor: 4.096
  10 in total

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