| Literature DB >> 15273284 |
Aubry K Miller1, Daniel H Byun, Christopher M Beaudry, Dirk Trauner.
Abstract
The total synthesis of the molluscan polypropionate (-)-crispatene is described. The synthesis features a palladium-catalyzed cross-coupling to establish a sensitive conjugated tetraene and its Lewis acid-catalyzed cycloisomerization to yield the bicyclo[3.1.0]hexene core of the natural product. The absolute configuration of (-)-crispatene and related molecules is established.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15273284 PMCID： PMC514427 DOI： 10.1073/pnas.0401787101
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205