Literature DB >> 11560372

SNF4435C and D, novel immunosuppressants produced by a strain of Streptomyces spectabilis. II. Structure elucidation.

K Takahashi1, E Tsuda, K Kurosawa.   

Abstract

SNF4435C and D are new immunosuppressants isolated from the culture broth of a strain of Streptomyces spectabilis. Their molecular formulas were determined as C28H31NO6 based on the HRFAB-MS analyses. The structures of SNF4435C and D were elucidated to be novel nitrophenyl pyrones having an intriguing tricyclic ring system and diastereoisomers of each other by spectroscopic analyses including various NMR measurements.

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Year:  2001        PMID： 11560372     DOI： 10.7164/antibiotics.54.548

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  7 in total

1.  Synthesis and SAR of Lehualide B: a marine-derived natural product with potent anti-multiple myeloma activity.

Authors:  Valer Jeso; Chunying Yang; Michael D Cameron; John L Cleveland; Glenn C Micalizio
Journal:  ACS Chem Biol       Date:  2013-04-02       Impact factor: 5.100

2.  Total synthesis of the potent androgen receptor antagonist (-)-arabilin: a strategic, biomimetic [1,7]-hydrogen shift.

Authors:  Hee Nam Lim; Kathlyn A Parker
Journal:  J Am Chem Soc       Date:  2011-11-29       Impact factor: 15.419

3.  Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues.

Authors:  Martina Werneburg; Benjamin Busch; Jing He; Martin E A Richter; Longkuan Xiang; Bradley S Moore; Martin Roth; Hans-Martin Dahse; Christian Hertweck
Journal:  J Am Chem Soc       Date:  2010-08-04       Impact factor: 15.419

4.  The total synthesis of (-)-crispatene.

Authors:  Aubry K Miller; Daniel H Byun; Christopher M Beaudry; Dirk Trauner
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-23       Impact factor: 11.205

5.  Terminal substituent effects on the reactivity, thermodynamics, and stereoselectivity of the 8π-6π electrocyclization cascades of 1,3,5,7-tetraenes.

Authors:  Ashay Patel; K N Houk
Journal:  J Org Chem       Date:  2014-11-17       Impact factor: 4.354

6.  Reversal of multidrug resistance by novel nitrophenyl pyrones, SNF4435C and D.

Authors:  K Kurosawa; K Takahashi; E Tsuda; A Tomida; T Tsuruo
Journal:  Jpn J Cancer Res       Date:  2001-11

7.  Total synthesis of endiandric acid J and beilcyclone A from cyclooctatetraene.

Authors:  Oussama Yahiaoui; Adrian Almass; Thomas Fallon
Journal:  Chem Sci       Date:  2020-07-29       Impact factor: 9.825
  7 in total

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